具有新型效应子功能的重组抗体。
Recombinant antibodies possessing novel effector functions.
作者信息
Neuberger M S, Williams G T, Fox R O
出版信息
Nature. 1984;312(5995):604-8. doi: 10.1038/312604a0.
DOI:10.1038/312604a0
PMID:6095112
Abstract
The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.
摘要
将体外操作的免疫球蛋白基因DNA导入淋巴细胞可产生新型抗体。通过这种方式，已建立了分泌半抗原特异性抗体的细胞系，其中Fc部分已被活性酶部分或展示c-myc抗原决定簇的多肽所取代。
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