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深入探讨 HIV 抗体检测:1. 它们的准确性如何?

A Critical Look at HIV-Antibody Tests: 1. How Accurate Are They?

出版信息

Can Fam Physician. 1987 Sep;33:2005-11.

PMID:21263971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2218634/
Abstract

As the AIDS epidemic spreads, many patients are asking their primary-care physicians to perform AIDS (HIV-antibody) testing, and in some settings, clinical circumstances prompt physicians to consider ordering the test. As a result, thousands of HIV-antibody tests are being requested each month by Canadian family doctors, where none were available only two years ago. Yet particular characteristics of HIV infection make these tests very unlike most blood tests, since their use carries clear risks as well as benefits. The authors review these risks and benefits in two sequential articles. In this first paper, they review the quantitative aspects of test accuracy (validity). In a sequential paper, to be published in next month's issue, they will discuss the risks and benefits of performing the test in various clinical circumstances.

摘要

随着艾滋病疫情的蔓延,许多患者要求他们的初级保健医生进行艾滋病(HIV 抗体)检测,在某些情况下,临床情况促使医生考虑开这种检测。结果,加拿大家庭医生每月要求进行数千次 HIV 抗体检测,而就在两年前,还根本无法进行这种检测。然而,HIV 感染的特殊特征使得这些检测与大多数血液检测非常不同,因为这些检测的使用既有明确的风险,也有好处。作者在两篇连续的文章中对这些风险和好处进行了回顾。在第一篇文章中,他们回顾了检测准确性(有效性)的定量方面。在下个月的下期,他们将在另一篇连续文章中讨论在各种临床情况下进行检测的风险和好处。

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引用本文的文献

1
A Critical Look at HIV-Antibody Tests: 2. Benefits, Risks and Clinical Use.审视HIV抗体检测:2. 益处、风险及临床应用
Can Fam Physician. 1987 Oct;33:2229-35.
2
When does a man need a check-up?男人什么时候需要做体检?
Can Fam Physician. 1988 Aug;34:1727-31.
3
AIDS and the Family Physician: Survey of Practices in AIDS Counselling and HIV Antibody Testing.艾滋病与家庭医生:艾滋病咨询和 HIV 抗体检测实践调查。
Can Fam Physician. 1990 Aug;36:1391-3.

本文引用的文献

1
The infectious complications of blood transfusion.输血的感染性并发症。
Can Fam Physician. 1987 May;33:1223-7.
2
Update on AIDS for the family physician.家庭医生的艾滋病最新情况
Can Fam Physician. 1987 May;33:1209-13.
3
Update: revised Public Health Service definition of persons who should refrain from donating blood and plasma--United States.更新:美国公共卫生服务局关于应避免献血和血浆者的修订定义
MMWR Morb Mortal Wkly Rep. 1985 Sep 6;34(35):547-8.
4
Assessment of screening as a preventive technology: the example of HTLV-III/LAV antibody testing.作为一种预防技术的筛查评估:以人类嗜T淋巴细胞病毒III型/淋巴腺病相关病毒抗体检测为例。
Isr J Med Sci. 1986 Jul-Aug;22(7-8):524-8.
5
Etiology and prevention of acquired immunodeficiency syndrome: the path of interdisciplinary research.获得性免疫缺陷综合征的病因与预防:跨学科研究之路
J Chronic Dis. 1986;39(12):1125-44. doi: 10.1016/0021-9681(86)90144-x.
6
Evaluation of a confidential method of excluding blood donors exposed to human immunodeficiency virus.评估一种用于排除接触过人类免疫缺陷病毒的献血者的保密方法。
Transfusion. 1986 Nov-Dec;26(6):539-41. doi: 10.1046/j.1537-2995.1986.26687043622.x.
7
Antibodies to HTLV-III/LAV in Venezuelan patients with acute malarial infections.委内瑞拉急性疟疾感染患者体内抗人类嗜T淋巴细胞病毒III型/淋巴腺病相关病毒抗体
N Engl J Med. 1986 Mar 6;314(10):647-8. doi: 10.1056/NEJM198603063141013.
8
Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events.内乳动脉移植对10年生存率及其他心脏事件的影响。
N Engl J Med. 1986 Jan 2;314(1):1-6. doi: 10.1056/NEJM198601023140101.
9
Screening for HIV: can we afford the false positive rate?HIV筛查:我们能否承受假阳性率?
N Engl J Med. 1987 Jul 23;317(4):238-41. doi: 10.1056/NEJM198707233170410.
10
Antigenemia and antibody titers to core and envelope antigens in AIDS, AIDS-related complex, and subclinical human immunodeficiency virus infection.艾滋病、艾滋病相关综合征及亚临床人类免疫缺陷病毒感染中针对核心抗原和包膜抗原的抗原血症及抗体滴度
J Infect Dis. 1987 Mar;155(3):558-60. doi: 10.1093/infdis/155.3.558.