Rakusan Karel
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario.
Exp Clin Cardiol. 2010 Winter;15(4):e100-3.
The safe use of drugs during pregnancy depends on several factors including the time of application, the type of drug and its dose. In the present review, the effect of certain therapeutic drugs on pregnancy is first described using general principles, followed by a more focused discussion on the type of adverse effects related to specific cardiovascular drugs used during pregnancy. In particular, adverse events related to the use of antihypertensive and antiarrhythmic drugs and anticoagulants are described, followed by the characterization of congenital cardiovascular defects resulting from the use of various drugs during pregnancy. Finally, various methods used to obtain information on the topic are described, and the need for carefully designed clinical trials is stressed.
孕期安全用药取决于几个因素，包括用药时间、药物类型及其剂量。在本综述中，首先使用一般原则描述某些治疗药物对妊娠的影响，随后更集中地讨论孕期使用的特定心血管药物相关的不良反应类型。特别描述了与使用抗高血压药、抗心律失常药和抗凝剂相关的不良事件，接着阐述了孕期使用各种药物导致的先天性心血管缺陷的特征。最后，描述了用于获取该主题信息的各种方法，并强调了精心设计的临床试验的必要性。
