对木鳖果（葫芦科）果肉提取物在血糖正常和四氧嘧啶诱导的高血糖大鼠中的降血糖活性评估。
Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan-Induced Hyperglycemic Rats.
作者信息
Jimam Ns, Wannang Nn, Omale S, Gotom B
机构信息
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria.
出版信息
J Young Pharm. 2010 Oct;2(4):384-7. doi: 10.4103/0975-1483.71633.
The hypoglycemic effects of the fruit extract of C. metuliferus was investigated in normoglycemic and alloxan-induced hyperglycemic rats. The results showed that there was an insignificant (P > 0.05) decrease in the blood glucose concentration of normoglycemic rats treated with oral doses of 1000 and 1500 mg/kg of the extract. On the other hand, 500 mg/kg of the fruit extract produced an insignificant (P > 0.05) decrease in blood glucose levels of alloxan-treated rats, while 1000 and 1500 mg/kg oral dose points produced a significant (P < 0.05) decrease in the blood glucose concentration of hyperglycemic rats comparable to that produced by tolbutamide. From this study, the data suggested that the fruit extract did not alter the BGC level in normoglycemic rats, but had a potential hypoglycemic property in alloxan-induced hyperglycemic rats.
在正常血糖和四氧嘧啶诱导的高血糖大鼠中研究了非洲吊灯树果实提取物的降血糖作用。结果表明，口服剂量为1000和1500 mg/kg提取物的正常血糖大鼠的血糖浓度有不显著的降低（P>0.05）。另一方面，500 mg/kg的果实提取物使四氧嘧啶处理大鼠的血糖水平有不显著的降低（P>0.05），而1000和1500 mg/kg口服剂量组使高血糖大鼠的血糖浓度有显著降低（P<0.05），与甲苯磺丁脲产生的降低效果相当。从这项研究来看，数据表明该果实提取物不会改变正常血糖大鼠的血糖水平，但在四氧嘧啶诱导的高血糖大鼠中具有潜在的降血糖特性。
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