Raman G V
St Mary's Hospital, Portsmouth, Hants.
Br J Clin Pract. 1990 Nov;44(11):508-9.
A 48-year-old woman presented with a three-week history of recurrent, generalised rash, flitting joint pains, frontal headache and shivering attacks. On admission she was pyrexial and exhibited a symmetrical generalised maculopapular rash with a few target lesions. The rash faded within the first 24 hours, but over the following week it recurred at intervals of 48 hours and was accompanied by fever and headache. She was started on a short course of steroids, which did not alter her symptoms or signs. Eight days after admission, the patient underwent a lumbar puncture, despite the absence of definite signs of meningeal irritation. The cerebrospinal fluid (CSF) was turbid and diagnostic of bacterial meningitis. Cultures of blood and CSF taken on the day of admission both grew Neisseria meningitidis. The patient was successfully treated; symptoms were completely resolved.
一名48岁女性,有反复出现的全身性皮疹、游走性关节疼痛、前额头痛和寒战发作3周病史。入院时发热,有对称性全身性斑丘疹,伴有一些靶形损害。皮疹在最初24小时内消退,但在接下来的一周内,每48小时复发一次,并伴有发热和头痛。她开始接受短期类固醇治疗,但症状和体征未改善。入院8天后,尽管没有明确的脑膜刺激征,患者仍接受了腰椎穿刺。脑脊液浑浊,诊断为细菌性脑膜炎。入院当天采集的血液和脑脊液培养物均培养出脑膜炎奈瑟菌。患者治疗成功,症状完全缓解。