Department of Gynecologic Oncology, The Second Affiliated Hospital of SunYat-sen University, 510120 Guangzhou, People's Republic of China.
Med Oncol. 2012 Jun;29(2):1242-8. doi: 10.1007/s12032-011-9830-2. Epub 2011 Jan 25.
Because altered microRNAs (miRNAs) expression patterns have been observed in a variety of diseased tissues, miRNA expression was compared in human cervical cancer tissues relative to adjacent normal cervical tissues in the present study. Microarray chips with 924 probes were used to detect the expression of miRNAs in cervical cancer tissue and adjacent normal cervical tissue of 13 patients with cervical cancer (11 squamous cervical cancers, one cervical adenocarcinoma, and one cervical sarcoma), all of whom were infected with human papilloma virus (HPV) 16 and/or HPV18. Compared to the expression levels in normal cervical tissues, 18 miRNAs (1.9%) were significantly upregulated (increase of ≥2×), and 19 miRNAs (2.1%) were significantly downregulated (decrease of ≤0.5×) in cervical cancer tissues. miRNA expression was independent of lymph node involvement, vascular invasion, and pathological differentiation. Taken together, cervical cancer tissues have altered expression of miRNAs relative to adjacent normal tissues. Further studies are necessary to determine whether aberrant miRNA expression is related to the pathogenesis of cervical cancer.
由于在各种病变组织中观察到了微小 RNA（miRNA）表达模式的改变，因此本研究比较了人宫颈癌组织与相邻正常宫颈组织中的 miRNA 表达。使用载有 924 个探针的微阵列芯片检测了 13 例宫颈癌患者（11 例宫颈鳞癌、1 例宫颈腺癌和 1 例宫颈肉瘤）的宫颈癌组织和相邻正常宫颈组织中 miRNA 的表达，所有患者均感染了人乳头瘤病毒（HPV）16 和/或 HPV18。与正常宫颈组织的表达水平相比，18 个 miRNA（1.9%）显著上调（增加≥2 倍），19 个 miRNA（2.1%）显著下调（减少≤0.5 倍）。miRNA 表达与淋巴结受累、血管浸润和病理分化无关。综上所述，宫颈癌组织相对于相邻正常组织存在 miRNA 表达的改变。需要进一步研究以确定异常 miRNA 表达是否与宫颈癌的发病机制有关。
