Divsion of Abdominal Cancer, Cancer Center of West China Hospital, SiChuan University, No 37, GuoXue Road, Chengdu, Sichuan Province 610041, China.
Med Oncol. 2012 Mar;29(1):140-3. doi: 10.1007/s12032-010-9804-9. Epub 2011 Jan 25.
Here, we presented a case of carcinosarcoma of the pancreas in a 53-year-old woman. The carcinosarcoma was in the head of pancreas. She underwent a pancreaticoduodenectomy. The tumor was grossly yellowish-whitish. Histologic evaluation of the tumor revealed 2 elements separated from each other. One component was conventional pancreatic ductal adenocarcinoma, and the other component showed sarcomatous growth pattern composed of pleomorphic spindle cells. Immunohistochemically, the adenocarcinoma component was reactive for antibodies to cytokeratin 18 and epithelial membrane antigen. The sarcomatous component was reactive for smooth muscle antibody. These findings led to a diagnosis of pancreatic carcinosarcoma. The patient was treated with gemcitabine, adriamycin, and cisplatin after the operation. Although previously reported patients with pancreatic carcinosarcoma showed a very poor outcome, this patient has remained free of recurrence for 20 months, which is the longest recurrence-free survival time recorded for this type of cancer. This treatment plan may be a feasible option.
在这里，我们报告了一例 53 岁女性胰腺的癌肉瘤病例。癌肉瘤位于胰腺头部。患者接受了胰十二指肠切除术。肿瘤大体上呈黄白色。肿瘤的组织学评估显示有 2 个彼此分离的成分。一个成分是常规的胰腺导管腺癌，另一个成分表现出多形性梭形细胞的肉瘤生长模式。免疫组化染色显示，腺癌成分对细胞角蛋白 18 和上皮膜抗原抗体有反应，而肉瘤成分对平滑肌抗体有反应。这些发现导致了胰腺癌肉瘤的诊断。术后患者接受了吉西他滨、阿霉素和顺铂治疗。尽管以前报道的胰腺癌肉瘤患者预后非常差，但该患者已经无复发地存活了 20 个月，这是此类癌症记录到的最长无复发生存时间。这种治疗方案可能是一种可行的选择。
