Tubman T R, Halliday H L, Normand C
Neonatal Intensive Care Unit, Royal Maternity Hospital, Belfast.
BMJ. 1990 Oct 13;301(6756):842-5. doi: 10.1136/bmj.301.6756.842.
To estimate the cost of treating babies with severe respiratory distress syndrome with natural porcine surfactant.
Retrospective controlled survey.
Regional neonatal intensive care unit, Belfast.
33 Preterm babies with severe respiratory distress syndrome who were enrolled in a European multicentre trial during 1985-7. 19 Babies were treated with surfactant and 14 served as controls.
Treatment with natural porcine surfactant.
Cost associated with surfactant replacement treatment per extra survivor in the treatment group and cost per quality adjusted life year for each extra survivor.
Fifteen (79%) of the 19 treated babies and five (36%) of the 14 control babies survived. On average, the control babies required 20 days in hospital compared with 61 days for the treated babies (or 95 [corrected] days per extra survivor in the treatment group). The cost per extra survivor in the treatment group was pounds 13,720, with the cost per quality adjusted life year estimated at pounds 710.
These costs compare favourably with those of established forms of treatment in adults. Thus surfactant replacement treatment for severe respiratory distress syndrome is fairly inexpensive and cost effective.
评估使用天然猪肺表面活性物质治疗患有严重呼吸窘迫综合征的婴儿的成本。
回顾性对照研究。
贝尔法斯特地区新生儿重症监护病房。
1985年至1987年期间参加一项欧洲多中心试验的33例患有严重呼吸窘迫综合征的早产儿。19例婴儿接受了表面活性物质治疗，14例作为对照。
使用天然猪肺表面活性物质进行治疗。
治疗组每多一名存活者与表面活性物质替代治疗相关的成本，以及每多一名存活者的每质量调整生命年成本。
19例接受治疗的婴儿中有15例（79%）存活，14例对照婴儿中有5例（36%）存活。平均而言，对照婴儿住院20天，而接受治疗的婴儿住院61天（或治疗组每多一名存活者住院95[校正后]天）。治疗组每多一名存活者的成本为13720英镑，每质量调整生命年成本估计为710英镑。
这些成本与成人现有治疗方法的成本相比具有优势。因此，严重呼吸窘迫综合征的表面活性物质替代治疗相当便宜且具有成本效益。
