Division of General Surgery, Department of Surgery, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan.
Surg Today. 2011 Feb;41(2):197-202. doi: 10.1007/s00595-009-4254-8. Epub 2011 Jan 26.
This study presents a new method that enables the detection of sentinel lymph nodes (SLN) with high sensitivity using indocyanine green (ICG) fluorescence imaging.
This study enrolled 128 patients with clinically node-negative breast cancer. Fluorescence imaging was obtained after ICG was injected into the areola. Subcutaneous lymphatic channels were immediately visible.
Lymphatic channels and SLN were successfully visualized in all patients. One lymphatic channel was 60%, two channels were 24%, and three channels were 16%. The number of fluorescence SLN ranged from 1 to 6, and blue-dyed SLN ranged from 0 to 3. In the latter, SLN were not identified in 44 patients. Nineteen patients had pathologically identified lymph node metastases. All of them were recognized by fluorescence imaging, but 8 patients had lymph nodes with metastases were not identified by dye method.
This ICG fluorescence imaging technique is feasible and safe for detecting SLN in a less invasive manner than conventional mapping, with real-time observations.
本研究提出了一种新方法，可使用吲哚菁绿（ICG）荧光成像实现高灵敏度的前哨淋巴结（SLN）检测。
本研究纳入了 128 例临床淋巴结阴性乳腺癌患者。在乳晕内注射 ICG 后获得荧光成像。皮下淋巴管立即可见。
所有患者的淋巴管和 SLN 均成功可视化。一条淋巴管占 60%，两条淋巴管占 24%，三条淋巴管占 16%。荧光 SLN 的数量从 1 到 6 不等，蓝色染色的 SLN 从 0 到 3 不等。在后一种情况下，44 名患者未识别出 SLN。19 名患者存在病理确认的淋巴结转移。所有这些都通过荧光成像识别，但 8 名患者的染料法未识别出有转移的淋巴结。
与传统的示踪方法相比，该 ICG 荧光成像技术更具侵入性，可实时观察，是一种可行且安全的检测 SLN 的方法。
