Peng Yong, Luo Xiao-jia, Chen Xiao-ping, Li Long-xin, Wan Li-yan, He Sen, Chen Xiao-ni, Wu Kai
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Nov;41(6):1034-8.
To study the relationship between PPARgamma2 Pro12Ala polymorphism and cognitive function in patients with primary hypertension.
This study enrolled 502 hypertensive patients of Chinese Han population from Jan 2008 to Feb 2009 in West China Hospital of Sichuan University. We collected the general data and applied the mini mental state examination (MMSE) to test the cognitive function and computed score. Total cholesterol (TC), triglyeride (TG), fasting plasma glucose (FPG) and postprandial blood sugar (PPBS), fasting insulin (FINS) and postprandial plasma insulin (PINS) were measured. PCR-RELP method was used to analysis the PPARgamma2 Pro12Ala gene polymorphism.
Pro12Pro genotype was present in 88.6% of the patients and Prol2Ala genotype was present in 11.4% of the population. Allele frequencies were 94.3% for Pro allele and 5.7% for Ala allele. In cognitive normal group, the frequencies of PP and PA genotype were 328 (87.2%) and 48 (12.8%), while the frequencies of PP and PA genotypes in the cognitive dysfunction group were 126 (92.9%), 9 (7.1%) respectively. Analyzed by chi2 test, both the genotype frequency and the allele frequency of PPARy2 Pro12Ala polymorphism did not display statistical variability between the cognitive normal group and the cognitive dysfunction group, even eliminating the influence of age and sexuality.
Pro12Ala polymorphism in PPARgamma2 with primary hypertension may not associate with cognitive impairment.
研究原发性高血压患者过氧化物酶体增殖物激活受体γ2（PPARγ2）Pro12Ala多态性与认知功能的关系。
本研究纳入了2008年1月至2009年2月四川大学华西医院的502例汉族高血压患者。收集一般资料，应用简易精神状态检查表（MMSE）测试认知功能并计算得分。检测总胆固醇（TC）、甘油三酯（TG）、空腹血糖（FPG）、餐后血糖（PPBS）、空腹胰岛素（FINS）和餐后血浆胰岛素（PINS）。采用聚合酶链反应-限制性片段长度多态性（PCR-RELP）方法分析PPARγ2 Pro12Ala基因多态性。
Pro12Pro基因型在88.6%的患者中存在，Pro12Ala基因型在11.4%的人群中存在。Pro等位基因频率为94.3%，Ala等位基因频率为5.7%。认知正常组中，PP和PA基因型频率分别为328例（87.2%）和48例（12.8%），而认知功能障碍组中PP和PA基因型频率分别为126例（92.9%）、9例（7.1%）。经卡方检验分析，即使排除年龄和性别的影响，PPARγ2 Pro12Ala多态性的基因型频率和等位基因频率在认知正常组和认知功能障碍组之间均未显示出统计学差异。
原发性高血压患者PPARγ2的Pro12Ala多态性可能与认知损害无关。
