Jezek P, Chalupa P, Horecká J, Kolácný I, Horák Z
Klinika infekcních chorob Masarykovy univerzity, Brno.
Vnitr Lek. 1990 Dec;36(12):1158-63.
Investigation of a group of 231 patients with viral hepatitis non-A, non-B (HNANB) revealed that the majority of cases is of the parenteral type (60.17%) and the remainder was without parenteral procedures. The course of HNANB was icteric in the majority (72.55%). On check-up examination one year after the onset of the acute stage the pathological clinical and laboratory finding, i.e. chronic liver disease still persisted in 31.6%. A follow-up of the patients in the course of six years revealed that the ratio of serious sequelae (chronic active hepatitis and cirrhosis of the liver) is significant and increases with time and thus already after two years these serious diagnoses predominate over the number of patients with chronic persistent hepatitis. The chi2 test revealed that there is no sexual difference as regards the development of the chronic stage of HNANB, that the chronic stage develops in both basic types of HNANB (in the parenteral and the epidemic type) but it is significantly more frequent in the parenteral type. The development of the chronic stage is equally frequent after icteric and anicteric forms. In patients who recovered completely within one year (68.39%) the convalescence was protracted and normalization of the clinical and biochemical finding occurred later than in patients with viral hepatitis A and B, hospitalized during the same period.
对231例非甲非乙型病毒性肝炎（HNANB）患者的调查显示，大多数病例为肠道外感染型（60.17%），其余病例无肠道外感染途径。HNANB病程多数为黄疸型（72.55%）。急性期发病一年后的检查发现，病理、临床及实验室检查结果，即慢性肝病仍在31.6%的患者中持续存在。对患者进行为期六年的随访发现，严重后遗症（慢性活动性肝炎和肝硬化）的比例显著，且随时间增加，因此两年后这些严重诊断的患者数量超过了慢性持续性肝炎患者。卡方检验显示，HNANB慢性期的发生在性别上无差异，两种基本类型的HNANB（肠道外感染型和流行型）均会发展为慢性期，但在肠道外感染型中更为常见。黄疸型和无黄疸型之后慢性期的发生频率相同。在一年内完全康复的患者（68.39%）中，恢复期延长，临床和生化检查结果的正常化比同期住院的甲型和乙型病毒性肝炎患者出现得晚。
