Immunology Program, Benaroya Research Institute, Seattle, Washington 98103, USA.
Nat Rev Immunol. 2011 Feb;11(2):119-30. doi: 10.1038/nri2916.
Forkhead box P3 (FOXP3)(+) regulatory T (T(Reg)) cells prevent autoimmune disease, maintain immune homeostasis and modulate immune responses during infection. To accomplish these tasks, T(Reg) cell activity is precisely controlled, and this requires T(Reg) cells to alter their migratory, functional and homeostatic properties in response to specific cues in the immune environment. We review progress in understanding the diversity of T(Reg) cells, T(Reg) cell function in different anatomical and inflammatory settings, and the influence of the immune environment on T(Reg) cell activity. We also consider how these factors affect immune-mediated disease in the contexts of infection, autoimmunity, cancer and transplantation.
叉头框蛋白 P3（FOXP3）（+）调节性 T（T（Reg））细胞可预防自身免疫性疾病，维持免疫稳态，并在感染过程中调节免疫反应。为了完成这些任务，T（Reg）细胞的活性受到精确控制，这需要 T（Reg）细胞根据免疫环境中的特定线索改变其迁移、功能和稳态特性。我们回顾了在理解 T（Reg）细胞的多样性、T（Reg）细胞在不同解剖和炎症环境中的功能以及免疫环境对 T（Reg）细胞活性的影响方面所取得的进展。我们还考虑了这些因素如何在感染、自身免疫、癌症和移植的背景下影响免疫介导的疾病。
