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Common disease: are causative alleles common or rare?

作者信息

Shields Robert

出版信息

PLoS Biol. 2011 Jan 18;9(1):e1001009. doi: 10.1371/journal.pbio.1001009.

Abstract
摘要

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本文引用的文献

1
The importance of synthetic associations will only be resolved empirically.
PLoS Biol. 2011 Jan 18;9(1):e1001008. doi: 10.1371/journal.pbio.1001008.
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Synthetic associations are unlikely to account for many common disease genome-wide association signals.
PLoS Biol. 2011 Jan 18;9(1):e1000580. doi: 10.1371/journal.pbio.1000580.
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Synthetic associations created by rare variants do not explain most GWAS results.
PLoS Biol. 2011 Jan 18;9(1):e1000579. doi: 10.1371/journal.pbio.1000579.
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Genomics: The search for association.
Nature. 2010 Oct 28;467(7319):1135-8. doi: 10.1038/4671135a.
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Rare variants create synthetic genome-wide associations.
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Linkage disequilibrium and the mapping of complex human traits.
Trends Genet. 2002 Jan;18(1):19-24. doi: 10.1016/s0168-9525(01)02550-1.
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On the allelic spectrum of human disease.
Trends Genet. 2001 Sep;17(9):502-10. doi: 10.1016/s0168-9525(01)02410-6.
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Are rare variants responsible for susceptibility to complex diseases?
Am J Hum Genet. 2001 Jul;69(1):124-37. doi: 10.1086/321272. Epub 2001 Jun 12.

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