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1
The importance of synthetic associations will only be resolved empirically.
PLoS Biol. 2011 Jan 18;9(1):e1001008. doi: 10.1371/journal.pbio.1001008.
2
Synthetic associations are unlikely to account for many common disease genome-wide association signals.
PLoS Biol. 2011 Jan 18;9(1):e1000580. doi: 10.1371/journal.pbio.1000580.
3
Synthetic associations in the context of genome-wide association scan signals.
Hum Mol Genet. 2010 Oct 15;19(R2):R137-44. doi: 10.1093/hmg/ddq368. Epub 2010 Aug 30.
4
Calibration of credibility of agnostic genome-wide associations.
Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):964-72. doi: 10.1002/ajmg.b.30721.
5
What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.
Int J Epidemiol. 2012 Feb;41(1):273-86. doi: 10.1093/ije/dyr178. Epub 2011 Dec 5.
6
Common disease: are causative alleles common or rare?
PLoS Biol. 2011 Jan 18;9(1):e1001009. doi: 10.1371/journal.pbio.1001009.
7
A genome-wide linkage and association study using COGA data.
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S128. doi: 10.1186/1471-2156-6-S1-S128.
8
From Galton to GWAS: quantitative genetics of human height.
Genet Res (Camb). 2010 Dec;92(5-6):371-9. doi: 10.1017/S0016672310000571.
10
Genetics of bipolar disorder: where we are and where we are going.
Depress Anxiety. 2012 Dec;29(12):991-3. doi: 10.1002/da.22028.

引用本文的文献

1
Two decades of association mapping: Insights on disease resistance in major crops.
Front Plant Sci. 2022 Dec 6;13:1064059. doi: 10.3389/fpls.2022.1064059. eCollection 2022.
2
Identification of pleiotropy at the gene level between psychiatric disorders and related traits.
Transl Psychiatry. 2021 Jul 29;11(1):410. doi: 10.1038/s41398-021-01530-4.
4
A novel linkage-disequilibrium corrected genomic relationship matrix for SNP-heritability estimation and genomic prediction.
Heredity (Edinb). 2018 Apr;120(4):356-368. doi: 10.1038/s41437-017-0023-4. Epub 2017 Dec 14.
5
Type 2 diabetes: genetic data sharing to advance complex disease research.
Nat Rev Genet. 2016 Sep;17(9):535-49. doi: 10.1038/nrg.2016.56. Epub 2016 Jul 11.
6
The genetic architecture of type 2 diabetes.
Nature. 2016 Aug 4;536(7614):41-47. doi: 10.1038/nature18642. Epub 2016 Jul 11.
8
Trans-ethnic meta-analysis of white blood cell phenotypes.
Hum Mol Genet. 2014 Dec 20;23(25):6944-60. doi: 10.1093/hmg/ddu401. Epub 2014 Aug 5.
9
Kidney disease: new technologies translate mechanisms to cure.
J Clin Invest. 2014 Jun;124(6):2294-8. doi: 10.1172/JCI76825. Epub 2014 Jun 2.
10
Windfalls and pitfalls: Applications of population genetics to the search for disease genes.
Evol Med Public Health. 2013 Jan;2013(1):254-72. doi: 10.1093/emph/eot021. Epub 2013 Nov 6.

本文引用的文献

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nat Genet. 2010 Nov;42(11):937-48. doi: 10.1038/ng.686. Epub 2010 Oct 10.
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Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature. 2010 Oct 14;467(7317):832-8. doi: 10.1038/nature09410. Epub 2010 Sep 29.
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Biological, clinical and population relevance of 95 loci for blood lipids.
Nature. 2010 Aug 5;466(7307):707-13. doi: 10.1038/nature09270.
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New findings in the genetics of major psychoses.
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Rare variants create synthetic genome-wide associations.
PLoS Biol. 2010 Jan 26;8(1):e1000294. doi: 10.1371/journal.pbio.1000294.
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Copy-number variants in neurodevelopmental disorders: promises and challenges.
Trends Genet. 2009 Dec;25(12):536-44. doi: 10.1016/j.tig.2009.10.006. Epub 2009 Nov 10.
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Finding the missing heritability of complex diseases.
Nature. 2009 Oct 8;461(7265):747-53. doi: 10.1038/nature08494.
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
Nature. 2009 Aug 6;460(7256):748-52. doi: 10.1038/nature08185. Epub 2009 Jul 1.
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On the allelic spectrum of human disease.
Trends Genet. 2001 Sep;17(9):502-10. doi: 10.1016/s0168-9525(01)02410-6.
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Are rare variants responsible for susceptibility to complex diseases?
Am J Hum Genet. 2001 Jul;69(1):124-37. doi: 10.1086/321272. Epub 2001 Jun 12.

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