The importance of synthetic associations will only be resolved empirically.
作者信息
Goldstein David B
机构信息
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America.
出版信息
PLoS Biol. 2011 Jan 18;9(1):e1001008. doi: 10.1371/journal.pbio.1001008.
Abstract
摘要
相似文献
1
The importance of synthetic associations will only be resolved empirically.合成关联的重要性只能通过实证来解决。
PLoS Biol. 2011 Jan 18;9(1):e1001008. doi: 10.1371/journal.pbio.1001008.
2
Synthetic associations are unlikely to account for many common disease genome-wide association signals.合成关联不太可能解释许多常见疾病的全基因组关联信号。
PLoS Biol. 2011 Jan 18;9(1):e1000580. doi: 10.1371/journal.pbio.1000580.
3
Synthetic associations in the context of genome-wide association scan signals.全基因组关联扫描信号背景下的合成关联。
Hum Mol Genet. 2010 Oct 15;19(R2):R137-44. doi: 10.1093/hmg/ddq368. Epub 2010 Aug 30.
4
Calibration of credibility of agnostic genome-wide associations.不可知全基因组关联的可信度校准。
Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):964-72. doi: 10.1002/ajmg.b.30721.
5
What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.全基因组显著阈值应为多少？边缘遗传关联的实证复制。
Int J Epidemiol. 2012 Feb;41(1):273-86. doi: 10.1093/ije/dyr178. Epub 2011 Dec 5.
6
Common disease: are causative alleles common or rare?常见疾病：致病等位基因是常见还是罕见？
PLoS Biol. 2011 Jan 18;9(1):e1001009. doi: 10.1371/journal.pbio.1001009.
7
A genome-wide linkage and association study using COGA data.使用 COGA 数据的全基因组连锁和关联研究。
BMC Genet. 2005 Dec 30;6 Suppl 1(Suppl 1):S128. doi: 10.1186/1471-2156-6-S1-S128.
8
From Galton to GWAS: quantitative genetics of human height.从高尔顿到全基因组关联研究：人类身高的数量遗传学
Genet Res (Camb). 2010 Dec;92(5-6):371-9. doi: 10.1017/S0016672310000571.
9
A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics.一种从汇总关联统计数据中估计区域遗传关联对复杂性状贡献的方法。
Sci Rep. 2016 Jun 8;6:27644. doi: 10.1038/srep27644.
10
Genetics of bipolar disorder: where we are and where we are going.
Depress Anxiety. 2012 Dec;29(12):991-3. doi: 10.1002/da.22028.
引用本文的文献
1
Two decades of association mapping: Insights on disease resistance in major crops.二十年的关联作图：对主要作物抗病性的见解
Front Plant Sci. 2022 Dec 6;13:1064059. doi: 10.3389/fpls.2022.1064059. eCollection 2022.
2
Identification of pleiotropy at the gene level between psychiatric disorders and related traits.鉴定精神障碍及其相关特征在基因水平上的多效性。
Transl Psychiatry. 2021 Jul 29;11(1):410. doi: 10.1038/s41398-021-01530-4.
3
The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies.在全基因组关联研究中，LD评分回归作为混杂因素和遗传相关性估计方法的准确性。
Genet Epidemiol. 2018 Dec;42(8):783-795. doi: 10.1002/gepi.22161. Epub 2018 Sep 24.
4
A novel linkage-disequilibrium corrected genomic relationship matrix for SNP-heritability estimation and genomic prediction.一种用于 SNP 遗传力估计和基因组预测的新型连锁不平衡校正基因组关系矩阵。
Heredity (Edinb). 2018 Apr;120(4):356-368. doi: 10.1038/s41437-017-0023-4. Epub 2017 Dec 14.
5
Type 2 diabetes: genetic data sharing to advance complex disease research.2 型糖尿病：遗传数据共享以推进复杂疾病研究。
Nat Rev Genet. 2016 Sep;17(9):535-49. doi: 10.1038/nrg.2016.56. Epub 2016 Jul 11.
6
The genetic architecture of type 2 diabetes.2型糖尿病的遗传结构
Nature. 2016 Aug 4;536(7614):41-47. doi: 10.1038/nature18642. Epub 2016 Jul 11.
7
Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.与HIV-1感染相关的新遗传位点，与HIV复制和感染性存在假定调控联系：一项全基因组关联研究
PLoS One. 2015 Mar 18;10(3):e0118149. doi: 10.1371/journal.pone.0118149. eCollection 2015.
8
Trans-ethnic meta-analysis of white blood cell phenotypes.白细胞表型的跨种族荟萃分析。
Hum Mol Genet. 2014 Dec 20;23(25):6944-60. doi: 10.1093/hmg/ddu401. Epub 2014 Aug 5.
9
Kidney disease: new technologies translate mechanisms to cure.肾脏疾病：新技术将机制转化为治疗方法。
J Clin Invest. 2014 Jun;124(6):2294-8. doi: 10.1172/JCI76825. Epub 2014 Jun 2.
10
Windfalls and pitfalls: Applications of population genetics to the search for disease genes.意外收获与陷阱：群体遗传学在疾病基因搜索中的应用。
Evol Med Public Health. 2013 Jan;2013(1):254-72. doi: 10.1093/emph/eot021. Epub 2013 Nov 6.
本文引用的文献
1
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.对 249796 人的关联分析揭示了 18 个与体重指数相关的新位点。
Nat Genet. 2010 Nov;42(11):937-48. doi: 10.1038/ng.686. Epub 2010 Oct 10.
2
Hundreds of variants clustered in genomic loci and biological pathways affect human height.数以百计的变异体聚集在基因组位置和生物途径中，影响人类身高。
Nature. 2010 Oct 14;467(7317):832-8. doi: 10.1038/nature09410. Epub 2010 Sep 29.
3
Biological, clinical and population relevance of 95 loci for blood lipids.95 个与血脂相关的生物学、临床和人群相关性位点。
Nature. 2010 Aug 5;466(7307):707-13. doi: 10.1038/nature09270.
4
New findings in the genetics of major psychoses.重性精神病遗传学的新发现。
Dialogues Clin Neurosci. 2010;12(1):85-93. doi: 10.31887/DCNS.2010.12.1/mnoethen.
5
Rare variants create synthetic genome-wide associations.罕见变异导致全基因组关联合成。
PLoS Biol. 2010 Jan 26;8(1):e1000294. doi: 10.1371/journal.pbio.1000294.
6
Copy-number variants in neurodevelopmental disorders: promises and challenges.神经发育障碍中的拷贝数变异：前景与挑战。
Trends Genet. 2009 Dec;25(12):536-44. doi: 10.1016/j.tig.2009.10.006. Epub 2009 Nov 10.
7
Finding the missing heritability of complex diseases.寻找复杂疾病中缺失的遗传力。
Nature. 2009 Oct 8;461(7265):747-53. doi: 10.1038/nature08494.
8
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.常见的多基因变异会增加患精神分裂症和双相情感障碍的风险。
Nature. 2009 Aug 6;460(7256):748-52. doi: 10.1038/nature08185. Epub 2009 Jul 1.
9
On the allelic spectrum of human disease.关于人类疾病的等位基因谱。
Trends Genet. 2001 Sep;17(9):502-10. doi: 10.1016/s0168-9525(01)02410-6.
10
Are rare variants responsible for susceptibility to complex diseases?罕见变异是否与复杂疾病的易感性有关？
Am J Hum Genet. 2001 Jul;69(1):124-37. doi: 10.1086/321272. Epub 2001 Jun 12.
Zotero 插件