Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
J Nutr Health Aging. 2011 Jan;15(1):32-5. doi: 10.1007/s12603-011-0010-z.
To determine the association between long chain omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements intake and cognitive decline in an older Chinese population.
Prospective cohort study.
The Singapore Longitudinal Aging Studies (SLAS), a community-based study in urban region of Singapore.
1,475 Chinese adults aged ≥ 55 years.
Omega-3 PUFA supplements intake and Mini-Mental State Examination (MMSE) were assessed at baseline. MMSE was re-assessed at a median of 1.5 years after baseline and cognitive decline was defined as at least 2-points drop in MMSE score from baseline to follow-up. Odds ratios (ORs) of association between n-3 PUFA supplements intake and cognitive decline were calculated in logistic regression models controlling for baseline confounding variables.
Daily n-3 PUFA supplements intake was significantly (p=0.024) associated with lower risk of cognitive decline (OR=0.37, 95% C.I. 0.16-0.87) after controlling for age, gender, education, number of medical comorbidity, the presence of vascular risk factors/diseases, smoking, alcohol drinking, depression, APOE e4 allele carrier status, nutritional status, level of leisure activities, baseline MMSE and length of follow-up. The association remained significant (p=0.015) after excluding participants with baseline cognitive impairment (MMSE < 24), diabetes, stroke, and cardiac diseases (OR=0.23, 95% C.I. 0.07-0.75). No statistically significant association (OR=1.02, 95% C.I. 0.81-1.27) of fish consumption with cognitive decline was found.
Daily n-3 PUFA supplements consumption was independently associated with less cognitive decline in elderly Chinese.
在中国老年人群中，确定长链 ω-3 多不饱和脂肪酸（n-3 PUFA）补充剂摄入与认知能力下降之间的关联。
前瞻性队列研究。
新加坡老龄化纵向研究（SLAS），这是新加坡城市地区的一项社区研究。
1475 名年龄≥55 岁的中国成年人。
在基线时评估 ω-3 PUFA 补充剂摄入量和简易精神状态检查（MMSE）。在基线后中位数 1.5 年重新评估 MMSE，并将认知能力下降定义为 MMSE 评分从基线到随访至少下降 2 分。在控制基线混杂变量的逻辑回归模型中，计算 n-3 PUFA 补充剂摄入与认知能力下降之间关联的比值比（OR）。
在控制年龄、性别、教育程度、多种医疗合并症的数量、血管危险因素/疾病的存在、吸烟、饮酒、抑郁、APOE e4 等位基因携带状态、营养状况、休闲活动水平、基线 MMSE 和随访时间后，每日 n-3 PUFA 补充剂摄入与认知能力下降的风险显著降低（OR=0.37，95%置信区间 0.16-0.87，p=0.024）。在排除基线认知障碍（MMSE < 24）、糖尿病、中风和心脏病（OR=0.23，95%置信区间 0.07-0.75）患者后，该关联仍然显著（p=0.015）。吃鱼与认知能力下降之间没有统计学上显著的关联（OR=1.02，95%置信区间 0.81-1.27）。
在中国老年人中，每日 n-3 PUFA 补充剂的摄入与认知能力下降的发生率较低有关。
