Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Intensive Care Med. 2011 Apr;37(4):665-70. doi: 10.1007/s00134-011-2131-6. Epub 2011 Jan 26.
It is desirable to identify a potential organ donor (POD) as early as possible to achieve a donor conversion rate (DCR) as high as possible which is defined as the actual number of organ donors divided by the number of patients who are regarded as a potential organ donor. The DCR is calculated with different assessment tools to identify a POD. Obviously, with different assessment tools, one may calculate different DCRs, which make comparison difficult. Our aim was to determine which assessment tool can be used for a realistic estimation of a POD pool and how they compare to each other with regard to DCR.
Retrospective chart review of patients diagnosed with a subarachnoid haemorrhage, traumatic brain injury or intracerebral haemorrhage. We applied three different assessment tools on this cohort of patients.
We identified a cohort of 564 patients diagnosed with a subarachnoid haemorrhage, traumatic brain injury or intracerebral haemorrhage of whom 179/564 (31.7%) died. After applying the three different assessment tools the number of patients, before exclusion of medical reasons or age, was 76 for the IBD-FOUR definition, 104 patients for the IBD-GCS definition and 107 patients based on the OPTN definition of imminent neurological death. We noted the highest DCR (36.5%) in the IBD-FOUR definition.
The definition of imminent brain death based on the FOUR-score is the most practical tool to identify patients with a realistic chance to become brain dead and therefore to identify the patients most likely to become POD.
尽早确定潜在器官捐献者(POD),以尽可能提高供体转化率(DCR)。DCR 定义为实际器官捐献者数量与被视为潜在器官捐献者的患者数量之比。使用不同的评估工具来识别 POD,从而计算 DCR。显然,由于使用了不同的评估工具,可能会计算出不同的 DCR,这使得比较变得困难。我们的目的是确定哪种评估工具可用于对潜在器官捐献者群体进行现实估计,以及它们在 DCR 方面彼此之间的比较。
对被诊断为蛛网膜下腔出血、创伤性脑损伤或脑出血的患者进行回顾性图表审查。我们在该患者队列中应用了三种不同的评估工具。
我们确定了一个由 564 名被诊断为蛛网膜下腔出血、创伤性脑损伤或脑出血的患者组成的队列,其中 179/564(31.7%)死亡。在排除医疗原因或年龄限制后,应用三种不同的评估工具,IBD-FOUR 定义的患者人数为 76,IBD-GCS 定义的患者人数为 104,基于 OPTN 定义的 imminent neurological death 的患者人数为 107。我们注意到 IBD-FOUR 定义的 DCR 最高(36.5%)。
基于 FOUR-score 的脑死亡定义是识别具有真实脑死亡机会的患者并因此识别最有可能成为 POD 的患者的最实用工具。