Biomedicine and Sports Science Research Group, Edinburgh Napier University, Merchiston Campus, 10 Colinton Road, Edinburgh, EH10 5DT, UK.
Eur J Appl Physiol. 2011 Sep;111(9):2089-97. doi: 10.1007/s00421-011-1839-x. Epub 2011 Jan 26.
To investigate the acute effect of a hot, humid and ozone-polluted (O(3)) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean[Formula: see text]= 64.4 mlO(2) kg(-1) min(-1), SD = 4.4) took part in a time trial run in four different environmental conditions: 20°C + 50% relative humidity (rh) (Control); 20°C + 50% rh + 0.10 ppm O(3) (Control + O(3)); 31°C + 70% rh (Heat); 31°C + 70% rh + 0.10 ppm O(3) (Heat + O(3)). Blood samples and nasal lavage were collected post-exercise and analyzed for inflammatory, epithelial damage and oxidative stress markers. Data were analyzed using repeated measures ANOVA with Tukey's post hoc test. A significant increase in CC16 concentration (P < 0.05) and GSH/protein concentration (P < 0.05) in the upper respiratory airways was observed following the 8 km run in the Heat + O(3) trial compared with the control trial. There were no differences in the neutrophil counts between trials. No differences were observed for the other antioxidants analyzed. A hot, humid and ozone-polluted environment (0.1 ppm) elicits an early epithelial damage and antioxidant protection process in the upper respiratory airways of athletes immediately after performing 8 km time trial run.
为了研究炎热、潮湿且臭氧污染（O3）的环境对进行 8 公里计时赛跑步运动员肺部炎症和氧化应激的急性影响。采用单盲随机设计，10 名男性运动员（平均[公式：见正文] = 64.4 mlO2 kg-1 min-1，SD = 4.4）在四种不同环境条件下进行了计时赛：20°C + 50%相对湿度（rh）（对照）；20°C + 50% rh + 0.10 ppm O3（对照+ O3）；31°C + 70% rh（热）；31°C + 70% rh + 0.10 ppm O3（热+ O3）。运动后采集血液样本和鼻洗液，并分析炎症、上皮损伤和氧化应激标志物。使用重复测量方差分析和 Tukey 事后检验分析数据。与对照试验相比，在热+ O3 试验中，8 公里跑步后上呼吸道中 CC16 浓度（P < 0.05）和 GSH/蛋白浓度（P < 0.05）显著增加。各试验中性粒细胞计数无差异。分析的其他抗氧化剂也没有差异。在进行 8 公里计时赛后，运动员上呼吸道立即暴露在炎热、潮湿且臭氧污染（0.1 ppm）的环境中，会引发早期上皮损伤和抗氧化保护过程。
