Division of Biological Science and Technology, College of Science and Technology, Yonsei University, Wonju, Gangwon-Do, Republic of Korea.
J Cell Physiol. 2011 Apr;226(4):853-8. doi: 10.1002/jcp.22573.
Despite significant medical benefits as in space exploration or emergency care, prolonged torpidity of non-hibernator mammals remains unexplored to date. Here, we report that male Institute of Cancer Research mice could sustain two separate 2-day torpor bouts and maintain body temperature of 28-33°C following repeated treatments of 3-iodothyronamine (T(1) AM), a natural derivative of thyroid hormone. A 1-day interbout arousal period, adopted to mimic the behavior of true hibernators, seemed critical for the subjects to restore physiological homeostasis. Molecular studies of neuron-specific enolase, S100 calcium binding protein B and heat shock protein 72 suggested that the brain maintains functional and cytoprotective activities during sustained torpidity. Together, the results of this study propose a practical protocol using a torpor-arousal cycle that can be applied to the extreme medical situations.
尽管在太空探索或急救护理等方面具有重要的医学益处，但迄今为止，非冬眠哺乳动物的长期蛰伏状态仍未得到探索。在这里，我们报告说，雄性癌症研究所小鼠可以维持两次单独的为期两天的蛰伏期，并在多次接受 3-碘甲状腺原氨酸（T(1) AM）治疗后保持 28-33°C 的体温，T(1) AM 是甲状腺激素的一种天然衍生物。一天的中间觉醒期，旨在模拟真正冬眠动物的行为，对于受试者恢复生理平衡似乎至关重要。神经元特异性烯醇化酶、S100 钙结合蛋白 B 和热休克蛋白 72 的分子研究表明，大脑在持续蛰伏期间保持功能和细胞保护活性。总之，这项研究的结果提出了一种实用的方案，使用蛰伏-觉醒周期，可以应用于极端的医疗情况。
