Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
J Cell Physiol. 2012 Apr;227(4):1285-90. doi: 10.1002/jcp.22850.
Mammalian hibernation consists of periods of depressed metabolism and reduced body temperature called "torpor" that are interspersed by normothermic arousal periods. Numerous cellular processes are halted during torpor, including transcription, translation, and ion homeostasis. Hibernators are able to survive long periods of low blood flow and body temperature followed by rewarming and reperfusion without overt signs of organ injury, which makes these animals excellent models for application of natural protective mechanisms to human medicine. This review examines efforts to induce torpor-like states in non-hibernating species using pharmacological compounds. Elucidating the underlying mechanisms of natural and pharmacologically induced torpor will speed the development of new clinical approaches to treat a variety of trauma and stress states in humans.
哺乳动物的冬眠由代谢抑制和体温降低组成，称为“蛰伏”，其间穿插着正常体温的觉醒期。在蛰伏期间，许多细胞过程都会停止，包括转录、翻译和离子稳态。冬眠动物能够在长时间的低血流和体温后存活下来，然后复温再灌注，没有明显的器官损伤迹象，这使得这些动物成为将自然保护机制应用于人类医学的优秀模型。这篇综述检查了使用药物化合物在非冬眠物种中诱导类似蛰伏状态的努力。阐明自然和药理学诱导蛰伏的潜在机制将加速开发新的临床方法来治疗人类的各种创伤和应激状态。
