对胃肿瘤抑制因子 RUNX3 失活的新认识：幽门螺杆菌感染的作用。
New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infection.
机构信息
Department of Biochemistry, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
J Cell Biochem. 2011 Feb;112(2):381-6. doi: 10.1002/jcb.22964.
Abstract
Runt-related transcription factor 3, or RUNX3, is a tumor suppressor in gastric cancer. Inactivation of RUNX3 is causally associated with the genesis of gastric cancer, since RUNX3 is frequently inactivated in gastric cancers by hemizygous deletion, hypermethylation of its promoter, or protein mislocalization. Infection with Helicobacter pylori is the strongest risk factor for the development of gastric cancer. Recent studies have indicated that H. pylori infection plays an important role in the inactivation of RUNX3, and that this inactivation contributes to the pathogenesis of H. pylori. Here we summarize these recent advances and discuss their significances in understanding the initiation and development of gastric cancer.
摘要
runt 相关转录因子 3（RUNX3）是胃癌的一种肿瘤抑制因子。RUNX3 的失活与胃癌的发生有因果关系，因为 RUNX3 在胃癌中经常通过杂合性缺失、启动子超甲基化或蛋白定位错误而失活。幽门螺杆菌（H. pylori）感染是胃癌发展的最强危险因素。最近的研究表明，H. pylori 感染在 RUNX3 的失活中起重要作用，这种失活有助于 H. pylori 的发病机制。在这里，我们总结了这些最新进展，并讨论了它们在理解胃癌的发生和发展中的意义。
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