Division of Frontier Medical Science, Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
J Cell Biochem. 2011 Feb;112(2):387-93. doi: 10.1002/jcb.22967.
Cumulative evidences show that Runt-related transcription factor 3 (RUNX3) has a tumor suppressive role in various cancers. In particular, RUNX3 appears to be an important component of the transforming growth factor-β (TGF-β)-induced tumor suppression pathway. Contrary to reports on this tumor suppressive role of RUNX3, RUNX3 can also function as an oncogene when overexpressed. Recently, we found that RUNX3 overexpression was frequently observed and was well correlated with malignant behaviors in head and neck cancer, which is one of the most common types of human cancer. Moreover, it has been revealed that RUNX3 overexpression promoted cell growth and inhibited apoptosis in head and neck cancer cells. This review introduces the oncogenic role of RUNX3 in certain types of cancer including head and neck cancer.
累积的证据表明，Runt 相关转录因子 3（RUNX3）在各种癌症中具有肿瘤抑制作用。特别是，RUNX3 似乎是转化生长因子-β（TGF-β）诱导的肿瘤抑制途径中的重要组成部分。与 RUNX3 的肿瘤抑制作用的报道相反，当过度表达时，RUNX3 也可以作为癌基因发挥作用。最近，我们发现 RUNX3 的过表达在头颈部癌中经常观察到，并且与恶性行为密切相关，头颈部癌是最常见的人类癌症之一。此外，已经揭示了 RUNX3 的过表达促进了头颈部癌细胞的生长并抑制了细胞凋亡。本综述介绍了 RUNX3 在包括头颈部癌在内的某些类型的癌症中的致癌作用。
