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利托那韦诱导的急性肾损伤：肾活检结果及文献综述

Ritonavir-induced acute kidney injury: kidney biopsy findings and review of literature.

作者信息

Shafi T, Choi M J, Racusen L C, Spacek L A, Berry C, Atta M, Fine D M

机构信息

Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21224-2780, USA.

出版信息

Clin Nephrol. 2011 Feb;75 Suppl 1(0 1):60-4. doi: 10.5414/cn106469.

DOI:10.5414/cn106469
PMID:21269596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3727453/
Abstract

Ritonavir therapy is not generally considered nephrotoxic. We report a case of acute kidney injury secondary to ritonavir, with kidney biopsy demonstrating extensive acute tubular injury. This is the first report of a kidney biopsy and pathology in acute kidney injury associated with ritonavir. A review of published medical literature on the topic is also presented.

摘要

利托那韦疗法一般不被认为具有肾毒性。我们报告了一例继发于利托那韦的急性肾损伤病例，肾脏活检显示广泛的急性肾小管损伤。这是首例关于利托那韦相关急性肾损伤的肾脏活检及病理报告。本文还对该主题已发表的医学文献进行了综述。

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本文引用的文献

1
Glomerular lesions in HIV-positive patients: a 20-year biopsy experience from Northern Italy.HIV阳性患者的肾小球病变：来自意大利北部的20年活检经验
Clin Nephrol. 2009 Jul;72(1):38-45. doi: 10.5414/cnp72038.
2
Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel.成人HIV感染的抗逆转录病毒治疗：美国国际艾滋病协会专家组2008年建议
JAMA. 2008 Aug 6;300(5):555-70. doi: 10.1001/jama.300.5.555.
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Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions.替诺福韦相关的急慢性肾病：一例多种药物相互作用病例
Clin Infect Dis. 2006 Jan 15;42(2):283-90. doi: 10.1086/499048. Epub 2005 Dec 8.
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Two episodes of acute renal failure, rhabdomyolysis, and severe hepatitis in an AIDS patient successively treated with ritonavir and indinavir.
Clin Infect Dis. 1999 May;28(5):1180-1. doi: 10.1086/517777.
5
Interactions of HIV protease inhibitors with ATP-dependent drug export proteins.HIV蛋白酶抑制剂与ATP依赖性药物外排蛋白的相互作用。
Mol Pharmacol. 1999 Aug;56(2):383-9. doi: 10.1124/mol.56.2.383.
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Renal insufficiency induced by ritonavir in HIV-infected patients.利托那韦在HIV感染患者中引起的肾功能不全。
Am J Med. 1998 Nov;105(5):457.
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Pancreatorenal syndrome associated with combination antiretroviral therapy in HIV infection.与HIV感染的联合抗逆转录病毒治疗相关的胰肾综合征
Lancet. 1997 Jun 14;349(9067):1745-6. doi: 10.1016/S0140-6736(05)62957-1.
8
Side-effects of ritonavir and its combination with saquinavir with special regard to renal function.利托那韦及其与沙奎那韦联合使用的副作用，特别关注肾功能。
AIDS. 1997 May;11(6):836-8.
9
Ritonavir and renal failure.利托那韦与肾衰竭
N Engl J Med. 1997 Jan 9;336(2):138. doi: 10.1056/NEJM199701093360214.
10
Renal failure after treatment with ritonavir.利托那韦治疗后出现肾衰竭。
Lancet. 1996 Sep 7;348(9028):693. doi: 10.1016/S0140-6736(05)65125-2.