Duan Xin, Li Qi, Lin Li-jun, Liu Cheng-long, Li Zhi-hao, Liu Deng-jun, Zhang Fei
Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jan;31(1):117-20.
To detect the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with osteoarthritis and investigate their roles in the synovial lesions of osteoarthritis.
The expressions of HIF-1α and VEGF in the synovium were detected by immunohistochemical staining in 30 osteoarthritis cases, 20 acute traumatic arthritis cases and 10 normal synovial biopsy samples. The correlation between HIF-1α and VEGF, and their relationships with osteoarthritis were analyzed.
The rates of positive expression of HIF-1α and VEGF in osteoarthritis cases were significantly higher than those in acute traumatic arthritis (86.7% vs 60% and 80% vs 48%, P<0.05). Normal human synovium showed no positive expressions of HIF-1α and VEGF. HIF-1α expression was positively correlated to VEGF expression in acute traumatic synovitis and osteoarthritis cases, with correlation coefficients of 0.666 and 0.678, respectively.
The expressions of HIF-1α and VEGF in the synovial tissue are significantly higher in osteoarthritis cases than in cases of acute traumatic arthritis. They have close relationship in the synovial lesions of osteoarthritis and both contribute to the development of osteoarthritis.
检测骨关节炎患者缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）的表达，探讨其在骨关节炎滑膜病变中的作用。
采用免疫组织化学染色法检测30例骨关节炎患者、20例急性创伤性关节炎患者及10例正常滑膜活检标本中滑膜组织HIF-1α和VEGF的表达。分析HIF-1α与VEGF的相关性及其与骨关节炎的关系。
骨关节炎患者HIF-1α和VEGF的阳性表达率显著高于急性创伤性关节炎患者（86.7%对60%，80%对48%，P<0.05）。正常人滑膜组织未检测到HIF-1α和VEGF的阳性表达。急性创伤性滑膜炎和骨关节炎患者中，HIF-1α表达与VEGF表达呈正相关，相关系数分别为0.666和0.678。
骨关节炎患者滑膜组织中HIF-1α和VEGF的表达显著高于急性创伤性关节炎患者。它们在骨关节炎滑膜病变中关系密切，均参与骨关节炎的发生发展。
