IL1alpha-S100A13 异四聚体复合物结构：白细胞介素 1alpha 分泌的非经典途径的一个组成部分。
The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
出版信息
J Biol Chem. 2011 Apr 22;286(16):14608-17. doi: 10.1074/jbc.M110.201954. Epub 2011 Jan 26.
Abstract
Interleukin 1α (IL1α) plays an important role in several key biological functions, such as angiogenesis, cell proliferation, and tumor growth in several types of cancer. IL1α is a potent cytokine that induces a wide spectrum of immunological and inflammatory activities. The biological effects of IL1α are mediated through the activation of transmembrane receptors (IL1Rs) and therefore require the release of the protein into the extracellular space. IL1α is exported through a non-classical release pathway involving the formation of a specific multiprotein complex, which includes IL1α and S100A13. Because IL1α plays an important role in cell proliferation and angiogenesis, inhibiting the formation of the IL1α-S100A13 complex would be an effective strategy to inhibit a wide range of cancers. To understand the molecular events in the IL1α release pathway, we studied the structure of the IL1α-S100A13 tetrameric complex, which is the key complex formed during the non-classical pathway of IL1α release.
摘要
白细胞介素 1α（IL1α）在几种关键的生物学功能中发挥着重要作用，如几种类型癌症中的血管生成、细胞增殖和肿瘤生长。IL1α 是一种强效细胞因子，可诱导广泛的免疫和炎症活性。IL1α 的生物学效应是通过激活跨膜受体（IL1Rs）介导的，因此需要将蛋白质释放到细胞外空间。IL1α 通过涉及形成特定多蛋白复合物的非经典释放途径进行输出，该复合物包括 IL1α 和 S100A13。由于 IL1α 在细胞增殖和血管生成中发挥着重要作用，因此抑制 IL1α-S100A13 复合物的形成将是抑制广泛癌症的有效策略。为了了解 IL1α 释放途径中的分子事件，我们研究了 IL1α-S100A13 四聚体复合物的结构，这是 IL1α 非经典释放途径中形成的关键复合物。
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