Loiseau P, Yuen A W, Duché B, Ménager T, Arné-Bès M C
Department of Neurology, University Hospital, Bordeaux France.
Epilepsy Res. 1990 Nov;7(2):136-45. doi: 10.1016/0920-1211(90)90099-h.
Efficacy and safety of lamotrigine (LTG) as add-on therapy was assessed in a randomised double-blind placebo-controlled trial of this drug in 23 adult patients with refractory partial seizures. Fifteen patients showed an improvement on LTG treatment, with a greater than 50% decrease in total seizure count in 7 patients. Fourteen patients experienced fewer simple and complex partial seizures, with 8 patients benefitting by more than a 50% decrease in seizure frequency. The drug was well tolerated over the 2 month treatment period. The plasma concentration of concomitant antiepileptic drugs remained unchanged. No haematological or chemical abnormalities were noted.
