Calon B, Pottecher T, Frey A, Ravanello J, Otteni J C, Bach A C
Service d'Anesthésie et de Réanimation Chirurgicale, Hôpital de Hautepierre, Strasbourg, France.
Infusionstherapie. 1990 Oct;17(5):246-8. doi: 10.1159/000222495.
In order to assess the metabolic value of medium-chain triglycerides (MCT) in severely stressed intensive care unit patients, two fat emulsions containing either long-chain triglycerides (LCT), or a mixture of 50% MCT and 50% LCT were compared in 24 head trauma patients over a 10 day period. Variations of serum triglyceride, non-esterified fatty acid, glycerol and phospholipid concentrations remained comparable after both lipid infusions. Bilirubin, alkaline phosphatase and transaminase plasma levels were altered in both groups without any significant differences or clinical consequences. Cumulative nitrogen balance remained negative (-10 g N. day-1 i.e. -100 g N. 10 days-1) and comparable in both groups. However, thyroxin-binding prealbumin concentrations increased significantly in patients receiving the MCT/LCT mixture. It is concluded that MCT might have a beneficial effect on visceral protein metabolism after trauma.
为了评估中链甘油三酯（MCT）在重症加强护理病房（ICU）严重应激患者中的代谢价值，在24例头部创伤患者中，对两种脂肪乳剂进行了为期10天的比较，一种含长链甘油三酯（LCT），另一种含50%MCT与50%LCT的混合物。两种脂质输注后，血清甘油三酯、非酯化脂肪酸、甘油和磷脂浓度的变化仍具有可比性。两组患者的胆红素、碱性磷酸酶和转氨酶血浆水平均有改变，但无显著差异或临床后果。累积氮平衡仍为负值（-10 g N·天-1，即-100 g N·10天-1），两组相当。然而，接受MCT/LCT混合物的患者甲状腺素结合前白蛋白浓度显著升高。结论是，MCT可能对创伤后内脏蛋白代谢有有益作用。
