Dennison A R, Ball M, Hands L J, Crowe P J, Watkins R M, Kettlewell M
Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, England.
JPEN J Parenter Enteral Nutr. 1988 Jan-Feb;12(1):15-9. doi: 10.1177/014860718801200115.
Conventional long chain triglyceride (LCT) was compared with a new emulsion containing 50% medium chain triglyceride (5% MCT/5% LCT) in a randomized cross-over trial of 10 days duration. Plasma concentrations of albumin, prealbumin, the complement components C3 and C4, and prothrombin times measured daily at 8 am, before lipid infusion, showed no progressive change during the 10 days of the trial, nor in each separate 5-day period when LCT or MCT/LCT was infused. Aspartate transaminase and alkaline phosphatase activities were similar over the two periods. There was a significant increase (compared with preinfusion levels) in C3 and C4 levels after 5 hr of either lipid infusion. Nitrogen balance was improved, and plasma bilirubin levels were lower on the regimen containing MCT/LCT.
在一项为期10天的随机交叉试验中，将传统的长链甘油三酯（LCT）与一种含有50%中链甘油三酯（5% MCT/5% LCT）的新型乳剂进行了比较。在每天上午8点脂质输注前测量的白蛋白、前白蛋白、补体成分C3和C4的血浆浓度以及凝血酶原时间，在试验的10天期间没有呈现渐进性变化，在输注LCT或MCT/LCT的每个单独的5天期间也没有变化。两个时期的天冬氨酸转氨酶和碱性磷酸酶活性相似。在任何一种脂质输注5小时后，C3和C4水平均显著升高（与输注前水平相比）。含MCT/LCT的方案使氮平衡得到改善，血浆胆红素水平降低。
