Clarke P J, Ball M J, Hands L J, Dennison A R, Tunbridge A, White K, Kettlewell M G
Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK.
Br J Surg. 1987 Aug;74(8):701-4. doi: 10.1002/bjs.1800740818.
Lipid emulsions which contain long chain triglycerides (LCTs) provide a valuable energy source for patients requiring total parenteral nutrition (TPN). We have investigated the use of a new lipid emulsion containing both long and medium chain triglycerides (MCTs) in a randomized prospective trial. Sixty patients received TPN including 500 ml of either 20 per cent Lipofundin S (LCT) or Lipofundin 10 per cent MCT/10 per cent LCT for at least 6 days. Patients with renal or hepatic impairment, or major trauma, were excluded from the study. The MCT/LCT emulsion was found to be as safe and as effective a source of calories as LCT but the differences in metabolic parameters did not differ significantly between the two groups of patients. A lipid emulsion containing MCTs may have important advantages for seriously ill patients, but appears to have no obvious advantages for the majority of patients receiving TPN who are not severely stressed.
含有长链甘油三酯（LCT）的脂质乳剂为需要全胃肠外营养（TPN）的患者提供了宝贵的能量来源。我们在一项随机前瞻性试验中研究了一种同时含有长链和中链甘油三酯（MCT）的新型脂质乳剂的使用情况。60名患者接受了TPN，其中500毫升为20%的力保肪宁S（LCT）或10%的中链/10%的长链力保肪宁，持续至少6天。患有肾或肝功能损害或严重创伤的患者被排除在研究之外。发现中链/长链甘油三酯乳剂作为热量来源与长链甘油三酯一样安全有效，但两组患者的代谢参数差异无统计学意义。含有中链甘油三酯的脂质乳剂可能对重症患者具有重要优势，但对于大多数未受到严重应激的接受TPN的患者而言，似乎没有明显优势。
