Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
J Bioenerg Biomembr. 2011 Feb;43(1):81-8. doi: 10.1007/s10863-011-9331-1.
The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose.
机会性真菌感染的频率大幅增加，主要发生于因器官移植、白血病或 HIV 感染而免疫功能低下的患者中。尽管如此，抗真菌治疗仅可应用少数几类药物，且这些药物的作用靶点有限。因此，对于真菌感染的治疗，我们需要更具特异性且毒性更小的、针对新分子靶点的药物。在这种情况下，寻找哺乳动物线粒体和真菌中线粒体呼吸链经典和替代成分之间的差异，可能为此提供新的潜在治疗靶点。
