Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N3BG, UK.
Curr Pain Headache Rep. 2011 Apr;15(2):108-17. doi: 10.1007/s11916-011-0176-4.
Cluster headache is a highly disabling primary headache disorder, characterized by unilateral headache attacks occurring in association with cranial autonomic symptoms. Serotonergic agents, such as the ergot alkaloids, have traditionally been used for the acute and preventive treatment of cluster headache and other primary headaches. Although it initially was thought that their efficacy was due solely to the vasoconstriction of extracranial cerebral vessels, new mechanisms of action of these drugs have been ascertained as a consequence of advances in elucidation of the pathogenesis of primary headaches and the development of triptans. This article reviews the current knowledge about serotonergic agonists and antagonists used in the management of cluster headache, focusing on their mechanisms of action and on the possible role of serotonin system dysfunction in this complex disorder.
丛集性头痛是一种高致残性原发性头痛疾病，其特征为单侧头痛发作，伴有颅自主神经症状。5-羟色胺能药物，如麦角生物碱，传统上一直被用于丛集性头痛和其他原发性头痛的急性和预防性治疗。尽管最初认为它们的疗效仅归因于颅外脑血管的收缩，但随着原发性头痛发病机制的阐明和曲坦类药物的发展，这些药物的新作用机制已经确定。本文综述了目前用于治疗丛集性头痛的 5-羟色胺能激动剂和拮抗剂的知识，重点关注它们的作用机制以及 5-羟色胺系统功能障碍在这种复杂疾病中的可能作用。
