Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, North 13, West 7, Kita-ku, Sapporo, 060-8586, Japan.
Division of Neurology and Gastroenterology, Second Department of Internal Medicine, Fukui University, Matsuoka, Fukui, Japan.
Odontology. 2011 Jan;99(1):101-104. doi: 10.1007/s10266-010-0141-4. Epub 2011 Jan 27.
This report describes an episode of malignant hyperthermia (MH) in a 53-year-old Japanese man during general anesthesia that was triggered by isoflurane and succinylcholine. His past history and family history were unremarkable. From our analysis of ten exons, he had no recognizable mutation in the ryanodine receptor gene, but compatible with his MH reaction, he showed positive sensitivity to the Ca-induced Ca-release test. Histochemical and electron microscopic studies of muscle biopsy tissue demonstrated unusual "ring fibers," which have never before been reported to be associated with MH. The presence of ring fibers in this patient might indicate muscle regeneration, suggesting a recovery process from the MH episode.
本报告描述了一例 53 岁日本男性在全身麻醉期间因异氟烷和琥珀酰胆碱引发的恶性高热（MH）发作。他既往病史和家族史无异常。通过对十个外显子的分析，他的兰尼碱受体基因没有可识别的突变，但与他的 MH 反应一致，他对钙诱导的钙释放试验表现出阳性敏感性。肌肉活检组织的组织化学和电子显微镜研究显示出异常的“环纤维”，这在以前从未与 MH 相关报道过。该患者存在环纤维可能表明肌肉再生，提示从 MH 发作中恢复的过程。
