Ramirez J A, Cheetham E D, Laurence A S, Hopkins P M
Department of Anaesthetics, Royal Preston Hospital, UK.
Anaesthesia. 1998 Nov;53(11):1111-6. doi: 10.1046/j.1365-2044.1998.00562.x.
A 25-year-old man admitted with severe upper torso trauma displayed masseter muscle spasm after suxamethonium given during resuscitation. Anaesthesia was initially maintained with intravenous agents during transfer and X-ray angiography. However, during surgery to correct a brachial artery injury, malignant hyperthermia was triggered when isoflurane was given, 2.5 h after the suxamethonium. He responded to treatment, including dantrolene administration. Peak serum and urine myoglobin were 12,947 micrograms.l-1 and 54,571 micrograms.l-1, respectively, while maximum serum creatinine kinase was 17,300 IU. The patient made an uneventful recovery and later proved positive for malignant hyperthermia susceptibility on muscle contracture tests.
一名25岁男性因严重的上半身创伤入院，在复苏过程中给予琥珀胆碱后出现咬肌痉挛。在转运和X线血管造影期间，最初通过静脉用药维持麻醉。然而，在纠正肱动脉损伤的手术中，在给予琥珀胆碱2.5小时后使用异氟烷时引发了恶性高热。他对包括给予丹曲林在内的治疗有反应。血清和尿肌红蛋白峰值分别为12947微克/升和54571微克/升，而血清肌酸激酶最大值为17300国际单位。患者康复顺利，后来肌肉挛缩试验证明对恶性高热易感。
