药物线索消除学习的药理学增强：转化挑战。
Pharmacological enhancement of drug cue extinction learning: translational challenges.
机构信息
Laboratory of Behavioral Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA.
出版信息
Ann N Y Acad Sci. 2011 Jan;1216:122-37. doi: 10.1111/j.1749-6632.2010.05899.x.
Abstract
Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may constitute a rational strategy for the clinical management of drug relapse. While certain success has been reported for this form of therapy in anxiety disorders, in this paper we highlight several obstacles that may undermine the efficacy of exposure therapy for substance use disorders. We also review translational studies that have evaluated the facilitative effects of the cognitive enhancer D-cycloserine on extinction targeting drug-related cues. Finally, important considerations for the design and implementation of future studies evaluating exposure therapy combined with pharmacotherapy for substance use disorders are discussed.
摘要
线索暴露（消退）疗法结合认知增强型药物治疗可能是药物复吸临床管理的一种合理策略。尽管这种治疗形式在焦虑障碍中已经取得了一定的成功，但在本文中，我们强调了一些可能会破坏暴露疗法治疗物质使用障碍疗效的障碍。我们还回顾了评估认知增强剂 D-环丝氨酸对药物相关线索的消退作用的转化研究。最后，讨论了评估联合药物治疗物质使用障碍的暴露疗法的未来研究设计和实施的重要考虑因素。
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