School of Psychological Sciences, University of Manchester, Manchester, UK.
Early Interv Psychiatry. 2011 Feb;5(1):24-32. doi: 10.1111/j.1751-7893.2010.00254.x.
Much research has begun to focus on the identification of people who are at high risk of developing psychosis, and clinical services have been initiated for this population. However, only a small number of studies have reported on the efficacy of interventions for preventing or delaying the onset of psychosis. The results of prior work suggest that cognitive therapy (CT) may be an effective, well-tolerated treatment. We report on the rationale and design for a large-scale, multi-site randomized, controlled trial of CT for people who are assessed to be at high risk of psychosis because of either state or state-plus-trait risk factors.
The study employs a single-blind design in which all participants receive frequent mental-state monitoring, which will efficiently detect transition to psychosis, and half are randomized to weekly sessions of CT for up to 6 months. Participants will be followed-up for a minimum of 12 months and to a maximum of 2 years.
We report the characteristics of the final sample at baseline (n=288).
Our study aimed to expand the currently limited evidence base for best practice in interventions for individuals at high risk of psychosis.
大量研究开始集中于识别那些有发展为精神病高风险的人群，并为该人群启动了临床服务。然而，只有少数研究报告了预防或延迟精神病发作的干预措施的效果。先前工作的结果表明，认知疗法（CT）可能是一种有效且耐受良好的治疗方法。我们报告了一项大规模、多地点、随机、对照试验的基本原理和设计，该试验针对的是由于状态或状态加特质风险因素而被评估为有精神病高风险的人群，对他们进行 CT 治疗。
该研究采用单盲设计，所有参与者都接受频繁的精神状态监测，这将有效地检测到精神病的转变，其中一半参与者被随机分配到每周一次的 CT 治疗，持续长达 6 个月。参与者将至少随访 12 个月，最长随访 2 年。
我们报告了最终样本在基线时的特征（n=288）。
我们的研究旨在扩大目前针对精神病高危个体干预措施的最佳实践的有限证据基础。
