Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Exp Parasitol. 2011 Apr;127(4):727-31. doi: 10.1016/j.exppara.2011.01.013. Epub 2011 Jan 24.
Effective alternatives to anthelmintic treatment of nematode parasite infections of sheep are required because of the high prevalence of drug resistance. Within this context, the nematode-trapping fungus Duddingtonia flagrans has become a valuable component of various integrated control strategies. Toward this objective, a small quantity of lyophilized D. flagrans chlamydospores (10(6) spores per animal) was administered to sheep in a one-year plot study. Animals grazing on native pasture were divided into two homogeneous groups and were kept in 1-ha paddocks in the southern region of Brazil. The oral administration of chlamydospores led to a significant reduction (p<0.05) in the number of nematode eggs per gram of feces and in the larval availability on herbage (difference of 37.6%) in comparison to the control group. Control animals needed to be dewormed three times during the experiment, whereas the fungus-treated animals maintained a low parasite load, independent of seasonal variation. Although D. flagrans cannot serve as a panacea for nematode parasite control of livestock, it represents a significant advance toward rationalizing the use of endoparasitic drugs in small animals.
由于抗药性的普遍存在，需要寻找替代抗蠕虫药物治疗绵羊线虫寄生虫感染的有效方法。在这种情况下，食线虫真菌杜氏藻已成为各种综合控制策略的重要组成部分。为此，在为期一年的试验中，将少量冻干的杜氏藻厚垣孢子（每只动物 10(6) 个孢子）施用于绵羊。在巴西南部地区，放牧于原生牧场的绵羊被分为两组同质群体，并被安置在 1 公顷的围场内。与对照组相比，厚垣孢子的口服给药显著降低了粪便中每克粪便的线虫卵数和草皮上幼虫的可用性（差异为 37.6%）。在实验过程中，对照组动物需要驱虫 3 次，而真菌处理组动物保持低寄生虫负荷，不受季节性变化的影响。尽管杜氏藻不能作为控制家畜线虫寄生虫的万能药，但它代表了在小动物中合理使用内寄生虫药物的重要进展。
