Dabernat H, Avril J L, Boussougant Y
Laboratoire de Microbiologie, Centre Hospitalier Universitaire Purpan, Toulouse, France.
J Antimicrob Chemother. 1990 Dec;26 Suppl E:1-6. doi: 10.1093/jac/26.suppl_e.1.
The in-vitro activity of cefpodoxime, the active compound of the ester prodrug, cefpodoxime proxetil, was compared with that of other antibiotics. The susceptibility of bacterial isolates from patients with respiratory tract infections was determined by an agar dilution method. The MIC90s of cefpodozime for ampicillin-sensitive and beta-lactamase-producing strains of Haemophilus influenzae were 0.12 and 0.25 mg/l, respectively; the MIC90s for ampicillin-resistant non-beta-lactamase-producing strains was 1 mg/l. Time-kill curves of cefpodoxime against ampicillin-sensitive and ampicillin-resistant beta-lactamase producing strains showed a time-dependent bactericidal activity. The MIC90s for ampicillin-sensitive and ampicillin-resistant Branhamella catarrhalis were 0.50 and 1 mg/l, respectively. The MIC90s for penicillin-sensitive pneumococci, beta-haemolytic streptococci and Streptococcus agalactiae were 0.06, 0.06 and 0.12 mg/l, respectively. The inhibitory activity against penicillin-resistant pneumococci was limited: the MIC90 was 4 mg/l.
将酯前体药物头孢泊肟酯的活性化合物头孢泊肟的体外活性与其他抗生素进行了比较。采用琼脂稀释法测定呼吸道感染患者分离菌株的敏感性。头孢泊肟对流感嗜血杆菌氨苄西林敏感菌株和产β-内酰胺酶菌株的MIC90分别为0.12和0.25mg/l；对氨苄西林耐药的非产β-内酰胺酶菌株的MIC90为1mg/l。头孢泊肟对氨苄西林敏感和氨苄西林耐药的产β-内酰胺酶菌株的时间-杀菌曲线显示出时间依赖性杀菌活性。头孢泊肟对氨苄西林敏感和氨苄西林耐药的卡他莫拉菌的MIC90分别为0.50和1mg/l。对青霉素敏感的肺炎球菌、β-溶血性链球菌和无乳链球菌的MIC90分别为0.06、0.06和0.12mg/l。对青霉素耐药肺炎球菌的抑制活性有限：MIC90为4mg/l。
