Single-balloon versus double-balloon endoscopy for achieving total enteroscopy: a randomized, controlled trial.

BACKGROUND

Balloon endoscopy has been accepted as an effective tool for examining the small intestine. Two types of balloon endoscopy, single and double, are commercially available. The difference in performance between these 2 types of balloon endoscopy has not yet been elucidated.

OBJECTIVE

To compare the yield of single-balloon endoscopy (SBE) and double-balloon endoscopy (DBE).

DESIGN

Single-center, randomized, controlled trial.

SETTING

University hospital in Tokyo, Japan.

PATIENTS

Patients with suspected small-bowel disease.

INTERVENTIONS

SBE and DBE.

MAIN OUTCOME MEASUREMENTS

Outcomes were the total enteroscopy rate, diagnostic yield, complication rate, and clinical outcomes. Analysis was done by intent to treat.

RESULTS

The study started in April 2008 and was terminated in April 2010 because of an obvious disadvantage for the SBE group. Thirty-eight patients were enrolled in the study; 18 patients were assigned to the SBE group and 20 to the DBE group. The total enteroscopy rate was 0% in the SBE group and 57.1% in the DBE group (P = .002). In terms of complications, the DBE group had 1 patient with Mallory-Weiss syndrome, and the SBE group had 1 patient with hyperamylasemia. There was no difference in the overall diagnosis rate between the SBE and DBE groups (61.1% vs 50.0%, P = .49). There was no difference in therapeutic outcome between the SBE and DBE groups (27.8% vs 35.0%, P = .63).

LIMITATIONS

Relatively small number of study patients.

CONCLUSIONS

Total enteroscopy is more easily performed with DBE than with SBE.