Department of Biological Science and Technology, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, People's Republic of China.
Phytomedicine. 2011 Jun 15;18(8-9):731-8. doi: 10.1016/j.phymed.2010.11.014. Epub 2011 Jan 26.
Total saponins extracted from the caudexes and leaves of Panax notoginseng (SCLPN) have been used in the clinic for improving mental function, treating insomnia, and alleviating anxiety. The present study evaluated the potential antidepressant activity of SCLPN in rodent models of depression and the mechanism of action of SCLPN. Mice were received SCLPN at doses of 10-1000 mg/kg daily for 1, 7, and 14 days and then were subjected to the forced swim test and locomotor activity test. The results showed that SCLPN decreased immobility time in the forced swim test, with little effect on locomotion. In the chronic mild stress model, chronic SCLPN treatment (70 mg/kg) reversed the rats' depression-like behavior. Furthermore, SCLPN exerted its antidepressant-like effect by increasing the levels of 5-hydroxytryptamine, dopamine, and noradrenaline. Additionally, SCLPN treatment reduced intracellular Ca(2+) in cultured neurons. The present study suggests that SCLPN may function as an antidepressant, and the antidepressant-like effects of SCLPN may be mediated by modulation of brain monoamine neurotransmitters and intracellular Ca(2+) concentration.
从三七的根茎和叶中提取的总皂苷已在临床上用于改善精神功能、治疗失眠和缓解焦虑。本研究评估了 SCLPN 在抑郁动物模型中的潜在抗抑郁活性及其作用机制。小鼠每天接受 SCLPN 10-1000mg/kg 剂量治疗 1、7 和 14 天，然后进行强迫游泳试验和运动活性试验。结果表明，SCLPN 可减少强迫游泳试验中的不动时间，对运动影响不大。在慢性轻度应激模型中，慢性 SCLPN 治疗（70mg/kg）可逆转大鼠的抑郁样行为。此外，SCLPN 通过增加 5-羟色胺、多巴胺和去甲肾上腺素的水平发挥抗抑郁样作用。此外，SCLPN 处理可降低培养神经元中的细胞内 Ca(2+)。本研究表明，SCLPN 可能具有抗抑郁作用，SCLPN 的抗抑郁样作用可能是通过调节脑单胺神经递质和细胞内 Ca(2+)浓度来介导的。
