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三七对新型冠状病毒肺炎感染的潜在作用。

The potential of notoginseng against COVID-19 infection.

作者信息

Hu Yeye, He Ziliang, Zhang Wei, Niu Zhiqiang, Wang Yanting, Zhang Ji, Shen Ting, Cheng Hong, Hu Weicheng

机构信息

Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, 225009, China.

School of Life Sciences, Huaiyin Normal University, Huaian, 223300, China.

出版信息

J Ginseng Res. 2023 Apr 8;47(5):622-6. doi: 10.1016/j.jgr.2023.04.002.

DOI:10.1016/j.jgr.2023.04.002
PMID:37362082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10082468/
Abstract

The COVID-19 pandemic has changed the world and has presented the scientific community with unprecedented challenges. Infection is associated with overproduction of proinflammatory cytokines secondary to hyperactivation of the innate immune response, inducing a cytokine storm and triggering multiorgan failure and significant morbidity/mortality. No specific treatment is yet available. For thousands of years, notoginseng has been used to treat various infectious diseases. Experimental evidence of notoginseng utility in terms of alleviating the cytokine storm, especially the cascade, and improving post-COVID-19 symptoms, suggests that notoginseng may serve as a valuable adjunct treatment for COVID-19 infection.

摘要

新冠疫情改变了世界,给科学界带来了前所未有的挑战。感染与先天免疫反应过度激活继发的促炎细胞因子过度产生有关,引发细胞因子风暴,进而导致多器官功能衰竭和高发病率/死亡率。目前尚无特效治疗方法。数千年来,三七一直被用于治疗各种传染病。三七在减轻细胞因子风暴(尤其是级联反应)以及改善新冠后症状方面的实验证据表明,三七可能是新冠感染的一种有价值的辅助治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cff/10499578/360cc0274101/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cff/10499578/360cc0274101/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cff/10499578/360cc0274101/gr1.jpg

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Front Pharmacol. 2022 Jun 16;13:922337. doi: 10.3389/fphar.2022.922337. eCollection 2022.
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Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats.通过减轻大鼠炎症反应缓解脓毒症诱导的急性肾损伤
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Identification of anti-inflammatory components of raw and steamed root by analyses of spectrum-effect relationship.
通过谱效关系分析鉴定生地黄与熟地黄的抗炎成分。
RSC Adv. 2019 Jun 7;9(31):17950-17958. doi: 10.1039/c9ra00906j. eCollection 2019 Jun 4.
4
Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) improves renal mesangial cell damage in diabetic nephropathy by inhibiting the inflammatory response of infiltrated macrophages.黄芪和三七配方(A&P)通过抑制浸润巨噬细胞的炎症反应改善糖尿病肾病的肾小球系膜细胞损伤。
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Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials.草药材料的抗氧化、抗菌和抗病毒特性。
Antioxidants (Basel). 2020 Dec 21;9(12):1309. doi: 10.3390/antiox9121309.
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Front Immunol. 2020 Nov 30;11:570993. doi: 10.3389/fimmu.2020.570993. eCollection 2020.
7
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