College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
Bioorg Med Chem Lett. 2011 Feb 15;21(4):1279-81. doi: 10.1016/j.bmcl.2010.11.095. Epub 2010 Nov 25.
A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC(50) value of 10.4 and 3.8 μM, respectively.
从唇形科糙苏属植物美丽糙苏（Isodon excisus）的地上部分分离得到一个新的吡咯里西啶二萜，命名为 excisusin F（1），此外还分离得到 4 个已知化合物，通过 1D 和 2D NMR 以及质谱等方法确定了它们的结构。化合物 1 和 3 对 LPS 诱导的 RAW264.7 细胞产生的一氧化氮具有较强的抑制作用，IC50 值分别为 10.4 和 3.8 μM。
