University of Wisconsin-Milwaukee, 53201, USA.
Am J Alzheimers Dis Other Demen. 2011 Mar;26(2):145-50. doi: 10.1177/1533317510397329. Epub 2011 Jan 27.
Cortisol patterns in nursing home residents with dementia are described and examined in relation to cognition and comorbid illnesses. Saliva was sampled 4 times in a 24-hour period (week 1) and at the same times 1 week later (week 2). In general, cortisol levels decreased from morning to evening, with 50% exhibiting a negative slope. In contrast, 38% of the participants had a relatively flat cortisol diurnal rhythm, and 7% exhibited an afternoon increase. The cortisol pattern was consistent between weeks 1 and 2 for 39% with a negative slope, 13% with a flat profile, and for 2% with an afternoon increase pattern. Cortisol rhythm was not statistically significantly related to cognition or illness burden. While this study contributes to the understanding of differences in the diurnal pattern of cortisol for older adults with dementia, more research is needed to understand the etiology of the differences and the biological mechanisms involved.
描述了养老院痴呆症患者的皮质醇模式，并研究了其与认知和合并症的关系。在 24 小时内（第 1 周）和之后的同一时间（第 2 周）4 次采集唾液样本。一般来说，皮质醇水平从早上到晚上逐渐降低，有 50%表现出负斜率。相比之下，38%的参与者皮质醇昼夜节律相对平坦，7%的参与者下午皮质醇水平升高。对于有负斜率的参与者，皮质醇模式在第 1 周和第 2 周之间有 39%是一致的，有平坦模式的参与者占 13%，下午皮质醇水平升高的参与者占 2%。皮质醇节律与认知或疾病负担无统计学显著相关性。虽然这项研究有助于了解痴呆症老年患者皮质醇昼夜模式的差异，但需要进一步研究以了解差异的病因和涉及的生物学机制。
