Ho Rainbow Tin Hung, Cheung Jacob Kai Ki, Chan Wai Chi, Cheung Irene Kit Man, Lam Linda Chiu Wah
Centre on Behavioral Health, The University of Hong Kong, 2/F, The Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong, China.
Department of Social Work and Social Administration, The University of Hong Kong, Room 534, Jockey Club Tower, Centennial Campus, Hong Kong, China.
BMC Geriatr. 2015 Oct 19;15:127. doi: 10.1186/s12877-015-0123-z.
Dementia is characterized by a progressive decline and deterioration of brain regions such as memory, spatial navigation and language, along with disturbances in daily functioning. Non-pharmacological interventions that offer a holistic approach by targeting cognitive functioning, prognosis and the psychological and social effects of dementia require rigorous investigation. The well-established benefits of physical activity for cognitive functioning and psychological support in dementia have been observed with dance-movement intervention. There is substantial evidence that dance-movement interventions provide emotional and social advantages. Thus, a randomized controlled trial (RCT) is planned to investigate the positive effects of a dance movement intervention, compared with mild physical exercise, on the physical and psychological well-being of elderly Chinese individuals with early dementia.
METHODS/DESIGN: A 3-arm RCT with waitlist control design will be used in this study. Two hundred and one elderly participants with very mild to mild dementia will be screened and randomized into the following groups: (i) dance movement based intervention, (ii) stretching and exercise intervention and (iii) no intervention waitlist-control group. The two intervention groups will receive a 1-h intervention, twice a week, for 12 weeks. The participants will be assessed four times over the course of 12 months: baseline before randomization, post-intervention (3 months), 6 months from baseline and 12 months from baseline. The primary outcomes will be compared between assessment points and between groups on neuropsychiatric symptoms, psychosocial well-being and cognitive and daily functioning. Secondary outcomes will assess the changes in salivary cortisol levels and their relationships with the primary outcome measures.
This study will provide substantial evidence of the efficacy of a dance-movement-based intervention in slowing down dementia progression, due to its ability to act as a buffer against decline and improve areas affected by dementia. We also anticipate an association between cortisol levels and the outcome measures. The further development of this intervention into a structural program may be warranted for early psychosocial support among elderly populations.
The trial has been registered in the Chinese Clinical Trial Registry ( ChiCTR-IOR-15006541 ).
痴呆症的特征是大脑区域（如记忆、空间导航和语言）逐渐衰退和恶化，同时日常功能也受到干扰。通过针对认知功能、预后以及痴呆症的心理和社会影响提供整体方法的非药物干预措施需要进行严格调查。舞蹈运动干预已观察到身体活动对痴呆症患者认知功能和心理支持具有公认的益处。有大量证据表明舞蹈运动干预具有情感和社交优势。因此，计划进行一项随机对照试验（RCT），以研究与轻度体育锻炼相比，舞蹈运动干预对患有早期痴呆症的中国老年人身心健康的积极影响。
方法/设计：本研究将采用带有等待列表对照设计的三臂随机对照试验。将筛选201名患有极轻度至轻度痴呆症的老年参与者，并随机分为以下几组：（i）基于舞蹈运动的干预组，（ii）伸展和锻炼干预组，以及（iii）无干预等待列表对照组。两个干预组将每周接受两次为期1小时的干预，共12周。参与者将在12个月内接受四次评估：随机分组前的基线评估、干预后（3个月）、基线后6个月和基线后12个月。主要结局将在评估点之间以及组间比较神经精神症状、心理社会幸福感以及认知和日常功能。次要结局将评估唾液皮质醇水平的变化及其与主要结局指标的关系。
本研究将提供大量证据，证明基于舞蹈运动的干预在减缓痴呆症进展方面的有效性，因为它能够作为一种缓冲来抵御衰退并改善受痴呆症影响的区域。我们还预计皮质醇水平与结局指标之间存在关联。将这种干预进一步发展为结构化项目可能有必要为老年人群提供早期心理社会支持。
该试验已在中国临床试验注册中心注册（ChiCTR-IOR-15006541）。
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