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去甲肾上腺素对成年啮齿动物嗅球功能的调制的非线性影响。

Nonlinear effects of noradrenergic modulation of olfactory bulb function in adult rodents.

机构信息

Department of Neurobiology and Behavior, W245 Mudd Hall, Cornell University, Ithaca, NY 14853, USA.

出版信息

J Neurophysiol. 2011 Apr;105(4):1432-43. doi: 10.1152/jn.00960.2010. Epub 2011 Jan 27.

DOI:10.1152/jn.00960.2010
PMID:21273323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3075300/
Abstract

The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in acquisition of conditioned odor preferences in neonatal animals, in some species-specific odor-dependent behaviors, and in adult odor perception. We provide a detailed review of the functional role of NE in adult rodent main olfactory bulb function. We include cellular, synaptic, network, and behavioral data and use computational simulations to tie these different types of data together.

摘要

哺乳动物的嗅球主要从蓝斑接收大量的去甲肾上腺素能输入。去甲肾上腺素(NE)参与了新生动物条件性气味偏好的获得、某些特定于物种的气味依赖行为以及成年气味感知。我们提供了一个详细的综述,介绍了 NE 在成年啮齿动物嗅球功能中的功能作用。我们包括细胞、突触、网络和行为数据,并使用计算模拟将这些不同类型的数据联系起来。

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本文引用的文献

1
Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb.去甲肾上腺素对嗅球行为气味检测和辨别阈值的调制作用。
Eur J Neurosci. 2010 Aug;32(3):458-68. doi: 10.1111/j.1460-9568.2010.07297.x. Epub 2010 Jul 5.
2
Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of synchronized oscillations in the olfactory bulb.肾上腺素能受体介导的对心侧体细胞的去抑制作用触发嗅球中同步振荡的长期增强。
J Neurophysiol. 2010 Aug;104(2):665-74. doi: 10.1152/jn.00328.2010. Epub 2010 Jun 10.
3
Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells.α1 和 α2 去甲肾上腺素受体的激活对嗅球颗粒细胞的兴奋性产生相反的影响。
Neuroscience. 2010 Aug 25;169(2):882-92. doi: 10.1016/j.neuroscience.2010.05.010. Epub 2010 May 11.
4
Biophysical model for gamma rhythms in the olfactory bulb via subthreshold oscillations.嗅球亚阈值振荡的伽马节律生物物理模型。
Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21954-9. doi: 10.1073/pnas.0910964106. Epub 2009 Dec 8.
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Computing with dendrodendritic synapses in the olfactory bulb.嗅球中树突-树突突触的计算功能
Ann N Y Acad Sci. 2009 Jul;1170:264-9. doi: 10.1111/j.1749-6632.2009.03899.x.
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Noradrenergic regulation of GABAergic inhibition of main olfactory bulb mitral cells varies as a function of concentration and receptor subtype.去甲肾上腺素能对主嗅球二尖瓣细胞的γ-氨基丁酸能抑制的调节随浓度和受体亚型而变化。
J Neurophysiol. 2009 May;101(5):2472-84. doi: 10.1152/jn.91187.2008. Epub 2009 Mar 11.
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J Neurophysiol. 2009 May;101(5):2204-9. doi: 10.1152/jn.00076.2009. Epub 2009 Mar 4.
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Trends Neurosci. 2009 Apr;32(4):207-14. doi: 10.1016/j.tins.2008.11.008. Epub 2009 Feb 23.
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Bulbar acetylcholine enhances neural and perceptual odor discrimination.延髓乙酰胆碱可增强神经和嗅觉辨别能力。
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Noradrenergic induction of odor-specific neural habituation and olfactory memories.去甲肾上腺素能诱导气味特异性神经习惯化和嗅觉记忆。
J Neurosci. 2008 Oct 15;28(42):10711-9. doi: 10.1523/JNEUROSCI.3853-08.2008.