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β-内酰胺类-磷霉素拮抗作用涉及铜绿假单胞菌中青霉素结合蛋白3的修饰。

Beta-lactam-fosfomycin antagonism involving modification of penicillin-binding protein 3 in Pseudomonas aeruginosa.

作者信息

Reguera J A, Baquero F, Berenguer J, Martinez-Ferrer M, Martinez J L

机构信息

Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 1990 Nov;34(11):2093-6. doi: 10.1128/AAC.34.11.2093.

DOI:10.1128/AAC.34.11.2093
PMID:2127343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172005/
Abstract

Antagonism between fosfomycin and antipseudomonal penicillins, cefotaxime, and ceftriaxone was observed in Pseudomonas aeruginosa RYC212. Fosfomycin, a non-beta-lactam antibiotic that acts on bacterial cell wall synthesis, decreased the expression of penicillin-binding protein 3 and induced beta-lactamase. The antagonistic effect was reduced in the presence of high concentrations of the beta-lactamase inhibitor tazobactam or in fosfomycin-resistant mutants. We suggest that products resulting from fosfomycin cell wall damage could interact with a system that regulates penicillin-binding protein and beta-lactamase production.

摘要

在铜绿假单胞菌RYC212中观察到磷霉素与抗假单胞菌青霉素、头孢噻肟和头孢曲松之间存在拮抗作用。磷霉素是一种作用于细菌细胞壁合成的非β-内酰胺类抗生素，它可降低青霉素结合蛋白3的表达并诱导β-内酰胺酶的产生。在高浓度β-内酰胺酶抑制剂他唑巴坦存在的情况下或在磷霉素耐药突变体中，拮抗作用会减弱。我们认为，磷霉素导致的细胞壁损伤产物可能与调节青霉素结合蛋白和β-内酰胺酶产生的系统相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/655e/172005/40229e6455f2/aac00067-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/655e/172005/2886eb9d3e1f/aac00067-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/655e/172005/40229e6455f2/aac00067-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/655e/172005/2886eb9d3e1f/aac00067-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/655e/172005/40229e6455f2/aac00067-0078-b.jpg

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