腐生葡萄球菌耐甲氧西林菌株对β-内酰胺类抗生素耐药机制的特征分析
Characterization of mechanisms of resistance to beta-lactam antibiotics in methicillin-resistant strains of Staphylococcus saprophyticus.
作者信息
Stratton C W, Gelfand M S, Gerberding J L, Chambers H F
机构信息
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2561.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1780-2. doi: 10.1128/AAC.34.9.1780.
Abstract
The resistance mechanisms of methicillin-resistant strains of Staphylococcus saprophyticus were characterized. Penicillin-binding protein (PBP) studies demonstrated an inducible PBP identical to PBP 2a in the membranes of these isolates. The amount of beta-lactamase produced was minimal. PBP 2a is responsible for the methicillin resistance observed in these strains of S. saprophyticus.
摘要
对腐生葡萄球菌耐甲氧西林菌株的耐药机制进行了表征。青霉素结合蛋白（PBP）研究表明，这些分离株的膜中有一种可诱导的PBP，与PBP 2a相同。产生的β-内酰胺酶量极少。PBP 2a是这些腐生葡萄球菌菌株中观察到的甲氧西林耐药性的原因。
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