微管稳定化减少脊髓损伤后的瘢痕形成并促进轴突再生。
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.
机构信息
Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
出版信息
Science. 2011 Feb 18;331(6019):928-31. doi: 10.1126/science.1201148. Epub 2011 Jan 27.
Abstract
Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-β signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.
摘要
肥厚性瘢痕形成和固有轴突生长能力差是脊髓修复的主要障碍。这些过程受到微管动力学的严格调控。适度稳定微管可通过多种细胞机制减少损伤后脊髓中的瘢痕形成，包括抑制转化生长因子-β信号。它阻止硫酸软骨素蛋白聚糖的积累，并使病变部位有利于生长能力强的感觉神经元的轴突再生。微管稳定还促进了中脑-脊髓束 Raphe 神经元的中枢神经系统轴突的生长，并导致功能改善。因此，微管稳定减少纤维性瘢痕形成并增强轴突的生长能力。
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