Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan.
Invest Ophthalmol Vis Sci. 2011 Apr 1;52(5):2689-95. doi: 10.1167/iovs.10-6282.
To demonstrate the clinical application of a noninvasive, three-dimensional, vascular imaging technique called Doppler optical coherence angiography (OCA). To evaluate the vascular architecture of polypoidal choroidal vasculopathy (PCV) using Doppler OCA.
The authors prospectively examined the eyes of four healthy subjects and 15 PCV patients. Three-dimensional vascular flow imaging was performed using high-speed, high-resolution, and high-penetration spectral-domain Doppler optical coherence tomography. Two-dimensional images of the retina, choroid, and vascular lesions were obtained simultaneously.
Distribution of blood flow detected by Doppler OCA imaging corresponded well with that by indocyanine angiographic imaging. PCV lesions were localized in the space between the retinal pigment epithelium and the Bruch's membrane.
The authors found using Doppler OCA that PCV lesions are similar in architecture to choroidal neovascularization in age-related macular degeneration. Doppler OCA facilitates rapid and noninvasive examination of exudative macular diseases.
展示一种名为多普勒光相干血管造影（OCA）的无创、三维血管成像技术的临床应用。利用多普勒 OCA 评估息肉状脉络膜血管病变（PCV）的血管结构。
作者前瞻性地检查了 4 名健康受试者和 15 名 PCV 患者的眼睛。使用高速、高分辨率和高穿透性的谱域多普勒光相干断层扫描进行三维血流成像。同时获得视网膜、脉络膜和血管病变的二维图像。
多普勒 OCA 成像检测到的血流分布与吲哚菁绿血管造影成像的结果非常吻合。PCV 病变定位于视网膜色素上皮和布鲁赫膜之间的空间内。
作者通过多普勒 OCA 发现，PCV 病变的结构与年龄相关性黄斑变性的脉络膜新生血管相似。多普勒 OCA 便于快速、无创地检查渗出性黄斑疾病。
