Frame J D, Everitt A S, Gordon P W, Hackett M E
North East Thames Regional Burns and Plastic Surgery Unit, St. Andrew's Hospital, Billericay, Essex, UK.
Burns. 1990 Dec;16(6):437-40. doi: 10.1016/0305-4179(90)90073-6.
Sixteen children admitted to the North East Thames Regional Burn Unit, Billericay, were given immunoglobulin in the form of Sandoglobulin (0.3 g/kg body wt) between 36 h and 72 h after burn injury. In addition, children who developed a prodromal illness, similar to the toxic shock syndrome (TSS), prior to the administration of Sandoglobulin, were also given fresh frozen plasma and packed red blood cells where indicated. Mean serum levels of IgG1, IgG2 and IgG3 were obtained on a daily basis for the first 7 days postburn. All children survived the injury and a noticeable improvement in the clinical condition of the ill children was noted after immunoglobulin administration. A rise in serum levels of the subclasses investigated also correlated with the immunoglobulin administration and was sustained over the study period, which is the time a burned child is maximally at risk of developing TSS on our unit. There may be an 'at risk' group of children in the general population who have naturally low levels of serum IgG2.
16名入住位于比勒里基的东北泰晤士地区烧伤科的儿童，在烧伤后36小时至72小时之间接受了静脉注射用免疫球蛋白（商品名：沙格司亭，剂量为0.3g/kg体重）治疗。此外，在给予沙格司亭之前出现前驱疾病（类似于中毒性休克综合征）的儿童，在必要时还接受了新鲜冷冻血浆和浓缩红细胞治疗。在烧伤后的前7天，每天测定血清IgG1、IgG2和IgG3的平均水平。所有儿童均在烧伤后存活，并且在给予免疫球蛋白后，患病儿童的临床状况有明显改善。所研究的亚类血清水平的升高也与免疫球蛋白的给药相关，并且在研究期间保持稳定，而在本单位，这段时间是烧伤儿童发生中毒性休克综合征风险最高的时期。在普通人群中，可能存在血清IgG2水平自然较低的“高危”儿童群体。
