中毒性休克综合征患者血清IgG亚类模式失衡：针对中毒性休克综合征毒素1的特异性IgG1和IgG4亚类抗体缺乏

Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1.

作者信息

Christensson B, Johansson P J, Oxelius V A

出版信息

Clin Exp Immunol. 1986 Nov;66(2):443-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542541/

Abstract

An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immunity to TSST-1 in all four IgG subclasses. Normally acquired immunity to the toxin as well as the serological response developing in two patients with TSS was generally restricted to IgG1 and IgG4. A strong booster response of all four IgG subclasses was seen in three patients with S. aureus septicaemia due to TSST-1 producing strains. The lack of specific IgG1 and IgG4 antibodies to TSST-1 and the low serum IgG subclass levels found in the TSS-patients could be of pathogenetic significance and help to explain the susceptibility to TSS in certain individuals.

摘要

在10例中毒性休克综合征（TSS）患者中发现血清IgG亚类模式失衡，表现为各种组合的亚类水平显著降低。与正常对照组相比，IgG2水平显著降低。采用固相放射免疫分析法研究了针对中毒性休克综合征毒素（TSST-1）抗体的IgG亚类特异性。TSS患者在所有四个IgG亚类中均缺乏对TSST-1的预先免疫。正常获得的对该毒素的免疫力以及两名TSS患者中产生的血清学反应通常仅限于IgG1和IgG4。在3例由产生TSST-1的菌株引起的金黄色葡萄球菌败血症患者中，观察到所有四个IgG亚类都有强烈的增强反应。TSS患者中缺乏针对TSST-1的特异性IgG1和IgG4抗体以及血清IgG亚类水平较低可能具有致病意义，并有助于解释某些个体对TSS的易感性。