Chater S, Montgomery P
Can Fam Physician. 1985 Aug;31:1505-8.
The primary biochemical defect in Parkinsonism is dopamine depletion. Anticholinergics (except in the elderly) and amantadine are useful in treating early symptomatic disease. L-dopa remains the most effective drug, but experience has led to more modest use due to its late complications, particularly dyskinesias. Bromocriptine, a dopamine agonist, is relatively effective, but when it should be used is undecided. Beta-blockers may control tremor. Treatment should be tailored to each patient, and focus on functional motor ability. Dyskinesias and neuropsychiatric complications are the major limiting factors with most of these drugs. Several drugs are under investigation.
帕金森病的主要生化缺陷是多巴胺耗竭。抗胆碱能药物（老年人除外）和金刚烷胺对治疗早期症状性疾病有用。左旋多巴仍然是最有效的药物，但由于其晚期并发症，尤其是运动障碍，其使用已变得较为谨慎。多巴胺激动剂溴隐亭相对有效，但何时使用尚无定论。β受体阻滞剂可能控制震颤。治疗应根据每个患者量身定制，并侧重于功能性运动能力。运动障碍和神经精神并发症是这些药物中大多数的主要限制因素。几种药物正在研究中。
